Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species

Joint Authors

Agegnehu, Asnakech
Worku, Mesfin
Nigussie, Demiss
Lulu, Birhanu
Tadesse, Birkneh Tilahun

Source

BioMed Research International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-02

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Background.

Over the past decade, drug resistance pattern has worsened for many of the uropathogens due to overuse of antibiotics for empiric treatment.

The burden of extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae associated urinary tract infections (UTI) has become increasingly more common, limiting treatment options among children presenting with febrile UTI.

We investigated the burden and correlates of ESBL producing Enterobacteriaceae associated UTI among children and antibacterial resistance pattern.

Methods.

284 midstream urine specimens were collected using standard aseptic techniques from 284 children who were diagnosed with suspected UTI.

Urine culture and bacteria isolation were performed following standard bacteriological techniques.

The Kirby-Bauer disk diffusion technique and the double-disc synergy test were used to investigate antibiotic susceptibility and presence of ESBL production.

Results.

UTI was confirmed using a positive urine culture for a relevant pathogen in 96/284 (33.8%) of the cases.

Enterobacteriaceae accounted for 75% (72/96) of etiologies of UTI in children.

The most frequent Enterobacteriaceae spp.

were E.

coli, 44.4% (32/72) and K.

pneumonia, 27.8% (20/72).

The overall multidrug resistance rate was 86.1% (62/72).

ESBL-producers accounted for 41.7% (30/72) of the isolated Enterobacteriaceae.

ESBL producing K.

pneumonia and E.

coli isolates accounted for 70% (14/20) and 37.5% (12/32), respectively.

History of UTI in the past 1 year (adjusted odds ratio AoR=0.08,95%CI 0.01−0.57) and medium family wealth index (AoR=0.03,95%CI 0.00−0.27) protected from infection with ESBL-producing Enterobacteriaceae.

Conclusion.

ESBL production was more common in K.

pneumonia and appeared to be a major factor contributing drug resistance UTI in children.

The findings call for the need to incorporate ESBL testing in the routine clinical practice.

The resistance level to commonly prescribed first-line antibiotics observed within Enterobacteriaceae was alarming calling for strengthened antimicrobial stewardship.

American Psychological Association (APA)

Agegnehu, Asnakech& Worku, Mesfin& Nigussie, Demiss& Lulu, Birhanu& Tadesse, Birkneh Tilahun. 2020. Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1136099

Modern Language Association (MLA)

Agegnehu, Asnakech…[et al.]. Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1136099

American Medical Association (AMA)

Agegnehu, Asnakech& Worku, Mesfin& Nigussie, Demiss& Lulu, Birhanu& Tadesse, Birkneh Tilahun. Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1136099

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1136099