Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats
Joint Authors
Lee, Chien-Hsing
Lin, Chien-Liang
Wu, Chih-Chung
Huang, Guan-Cheng
Leung, Wan
Lee, Chining-Ting
Chen, Chung-Yi
Jeng, Jiiang H.
Hsieh, Shu-Ling
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-07
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) has been shown to have antioxidative and anti-inflammatory effects.
Oxidative and inflammatory reactions are related to the development of colorectal carcinoma (CRC).
In the present study, we characterized the preventive activities of THSG on colon carcinogenesis using the azoxymethane- (AOM-) mediated rat colon carcinogenesis model.
F344 male rats were randomly divided into 5 groups (untreated and AOM model rats treated with or without THSG at 30, 150, or 250 mg/kg) after which the numbers of aberrant crypt foci (ACF) were assessed in the colon tissues of all rats.
The expressions of nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2), matrix metalloproteinase proteins (MMPs), and carcinoembryonic antigen (CEA) were measured as effective early predictors of CRC using western blot analysis.
Treatment with THSG (150 or 250 mg/kg) induced a 50% reduction in total colonic ACF formation (P<0.05).
Furthermore, our results revealed a downregulation of CEA and NF-κB protein levels in the reduced number of ACF elicited by treatment with THSG, whereas levels of COX-2 and MMPs proteins were not changed.
Collectively, THSG may be a promising natural lead compound or drug candidate for treating early phases of CRC.
American Psychological Association (APA)
Lin, Chien-Liang& Jeng, Jiiang H.& Wu, Chih-Chung& Hsieh, Shu-Ling& Huang, Guan-Cheng& Leung, Wan…[et al.]. 2017. Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136170
Modern Language Association (MLA)
Lin, Chien-Liang…[et al.]. Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136170
American Medical Association (AMA)
Lin, Chien-Liang& Jeng, Jiiang H.& Wu, Chih-Chung& Hsieh, Shu-Ling& Huang, Guan-Cheng& Leung, Wan…[et al.]. Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136170
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136170