Circulating Interferon-λ3, Responsiveness to HBV Vaccination, and HBVHCV Infections in Haemodialysis Patients
Joint Authors
Grzegorzewska, Alicja E.
Mostowska, Adrianna
Jagodziński, Paweł P.
Świderska, Monika K.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The IFN-λ3 gene (IFNL3) plays a role in HCV clearance.
We investigated circulating IFN-λ3 and IFNL3 SNPs in haemodialysis patients who differed in their response to HBV vaccination and their HBV/HCV infection status.
In 201 patients, plasma IFN-λ3 was determined using ELISA.
IFNL3 SNPs (rs12979860, rs8099917) were genotyped using HRM analysis.
Differences in IFN-λ3 levels were shown between responders and nonresponders to HBV vaccination and between HBsAg-positive patients and those who developed anti-HBs after infection and became HBsAg negative.
HBV vaccine responders without HCV resolution revealed lower IFN-λ3 than noninfected responders.
HBsAg/HCV RNA-positive subjects showed lower IFN-λ3 than patients positive only for HCV RNA or subjects who resolved both infections.
Circulating IFN-λ3 correlated positively with anti-HBs and negatively with positive HCV RNA testing in the adjusted regression analyses.
HBV vaccine nonresponders, HBsAg-positive patients, and subjects with replicating HCV composed a group with unfavourable outcomes.
Responders to HBV vaccination, subjects who became HBsAg negative, and those who cleared HCV were analysed as having favourable outcomes.
The latter showed higher IFN-λ3 but did not differ in distribution of IFNL3 SNPs compared with subjects with unfavourable outcomes.
Higher IFN-λ3 concentrations are associated with response to HBV vaccination, self-limited HBV infection, and HCV resolution.
American Psychological Association (APA)
Grzegorzewska, Alicja E.& Świderska, Monika K.& Mostowska, Adrianna& Jagodziński, Paweł P.. 2017. Circulating Interferon-λ3, Responsiveness to HBV Vaccination, and HBVHCV Infections in Haemodialysis Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1136279
Modern Language Association (MLA)
Grzegorzewska, Alicja E.…[et al.]. Circulating Interferon-λ3, Responsiveness to HBV Vaccination, and HBVHCV Infections in Haemodialysis Patients. BioMed Research International No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1136279
American Medical Association (AMA)
Grzegorzewska, Alicja E.& Świderska, Monika K.& Mostowska, Adrianna& Jagodziński, Paweł P.. Circulating Interferon-λ3, Responsiveness to HBV Vaccination, and HBVHCV Infections in Haemodialysis Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1136279
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136279