Mammary and Extramammary Paget’s Disease Presented Different Expression Pattern of Steroid Hormone Receptors
Joint Authors
Mai, Ruiqin
Zhang, Guohong
Zhou, Songxia
Zhong, Weixiang
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Objectives.
Paget’s disease (PD) is a rare intraepithelial adenocarcinoma, which is composed of mammary (MPD) and extramammary Paget’s disease (EMPD).
Currently, the published literature contains scant data on expression pattern of steroid hormone receptors in MPD and EMPD.
Methods.
Expression of estrogen receptor (ER) and androgen receptor (AR) was evaluated in 88 MPD and 72 EMPD by using immunohistochemical staining and H-score method.
Results.
Positive expression of AR was significantly higher in EMPD (61.11%, 44/72) than in MPD (32.95%, 29/88) (P<0.001), while ER expression was positive 19.44% (14/72) in EMPD and only 9.09% (8/88) in MPD (P=0.059).
ER-AR expression pattern was significantly different between MPD (3.41%, 3/88) and EMPD (16.67%, 12/72) (P<0.001).
No difference of AR (P=0.301) or ER (P=0.239) expression was identified between invasive (48.57%, 51/105 of AR, and 11.43%, 12/105 of ER) and noninvasive PD.
In MPD, no difference of AR expression between MPD alone (7/18, 38.89%) and MPD with underling ductal carcinoma of breast (22/70, 31.43%) was identified (P=0.548).
In EMPD, expression of AR was 63.33% (38/60) in penoscrotal EMPD.
Conclusion.
Our current results indicate that MPD and EMPD presented different expression pattern of AR and ER and would help to further identify the molecular subtype of MPD and EMPD for adjuvant hormonal therapy, especially for patients with penoscrotal EMPD.
American Psychological Association (APA)
Zhou, Songxia& Zhong, Weixiang& Mai, Ruiqin& Zhang, Guohong. 2017. Mammary and Extramammary Paget’s Disease Presented Different Expression Pattern of Steroid Hormone Receptors. BioMed Research International،Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1136362
Modern Language Association (MLA)
Zhou, Songxia…[et al.]. Mammary and Extramammary Paget’s Disease Presented Different Expression Pattern of Steroid Hormone Receptors. BioMed Research International No. 2017 (2017), pp.1-5.
https://search.emarefa.net/detail/BIM-1136362
American Medical Association (AMA)
Zhou, Songxia& Zhong, Weixiang& Mai, Ruiqin& Zhang, Guohong. Mammary and Extramammary Paget’s Disease Presented Different Expression Pattern of Steroid Hormone Receptors. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-5.
https://search.emarefa.net/detail/BIM-1136362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1136362