LHPP Inhibits the Proliferation and Metastasis of Renal Cell Carcinoma

Joint Authors

Xiao, Jing
Kang, Huaning
Shi, Benyan
Li, Xiaofeng
Chen, Guihong
Zhang, Xiaoting

Source

BioMed Research International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-22

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Medicine

Abstract EN

Renal cell carcinoma (RCC) is one of the ten most common cancers in the globe.

Despite the diagnosis and treatment of renal cell carcinoma that have made great improvements, the morbidity and mortality rates of renal cell carcinoma remain unchanged remarkably.

LHPP is a kind of histidine phosphatases, acting as a tumor suppressor in the progression of various cancers.

In this study, we found that LHPP was significantly downregulated in RCC tissues and cell lines.

Decreased expression of LHPP was closely correlated with tumor size and postoperative metastasis of RCC patients.

In addition, overexpression of LHPP inhibited the proliferation and metastasis of RCC.

However, suppression of LHPP promoted the proliferation and metastasis of RCC.

In conclusion, our results presented the important role of LHPP in the development and progression of RCC.

American Psychological Association (APA)

Zhang, Xiaoting& Kang, Huaning& Xiao, Jing& Shi, Benyan& Li, Xiaofeng& Chen, Guihong. 2020. LHPP Inhibits the Proliferation and Metastasis of Renal Cell Carcinoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136416

Modern Language Association (MLA)

Zhang, Xiaoting…[et al.]. LHPP Inhibits the Proliferation and Metastasis of Renal Cell Carcinoma. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136416

American Medical Association (AMA)

Zhang, Xiaoting& Kang, Huaning& Xiao, Jing& Shi, Benyan& Li, Xiaofeng& Chen, Guihong. LHPP Inhibits the Proliferation and Metastasis of Renal Cell Carcinoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136416

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1136416