Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand
Joint Authors
Tongtawee, Taweesak
Kaewpitoon, Soraya
Dechsukhum, Chavaboon
Matrakool, Likit
Kaewpitoon, Natthawut
Panpimanmas, Sukij
Bartpho, Theeraya Simawaranon
Wattanawongdon, Wareeporn
Kangwantas, Kokiet
Kaengpenkae, Sivamate
Jintabanditwong, Nichaphat
Tangjanyatham, Pakorn
Ratchapol, Warisara
Leeanansaksiri, Wilairat
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Here we investigated CD44 protein expression and its polymorphisms in patients with chronic gastritis, precancerous gastric lesions, and gastric cancer; and we evaluated our result with the risk of CD44 protein expression and clinicopathological characteristics.
Our results obtained by analyzing 162 gastric cancer patients, 125 chronic gastritis, and 165 precancerous gastric lesions from three study centers in Thailand showed that CD44 expression was significantly higher in patients with precancerous gastric lesions and gastric cancer while patients with chronic gastritis were negative for CD44 staining (p=0.036).
We further observed the significant association of variant genotype; gastric cancer patients carrying AG or GG of CD44 rs187116 had more increased risk of CD44 expression than wild-type (WT) carriers (AG: odds ratio (OR) = 5.67; 95% CI = 1.57–7.23; p=0.024 and GG: OR = 8.32; 95% CI = 2.94–11.42; p=0.016), but no significant difference in the risk of CD44 expression due to polymorphism in patients with precancerous gastric lesions.
Our results suggested that CD44 expression could be used as a marker for the prediction of gastric cancer development, particularly in patients with precancerous gastric lesions carrying AG or GG, who were selected to surveillance follow-up for gastric cancer prevention.
American Psychological Association (APA)
Tongtawee, Taweesak& Wattanawongdon, Wareeporn& Bartpho, Theeraya Simawaranon& Kaewpitoon, Soraya& Kaengpenkae, Sivamate& Jintabanditwong, Nichaphat…[et al.]. 2017. Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137057
Modern Language Association (MLA)
Tongtawee, Taweesak…[et al.]. Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137057
American Medical Association (AMA)
Tongtawee, Taweesak& Wattanawongdon, Wareeporn& Bartpho, Theeraya Simawaranon& Kaewpitoon, Soraya& Kaengpenkae, Sivamate& Jintabanditwong, Nichaphat…[et al.]. Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137057