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Shin’iseihaito (Xinyiqingfeitang) Suppresses the Biofilm Formation of Streptococcus pneumoniae In Vitro
Joint Authors
Minami, Masaaki
Makino, Toshiaki
Takase, Hiroshi
Konishi, Toru
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Streptococcus pneumoniae (S.
pneumoniae) is the important pathogen that causes otolaryngeal diseases such as sinusitis.
S.
pneumoniae frequently forms the biofilm to prevent severe circumstances such as antimicrobial agents.
Shin’iseihaito (xinyiqingfeitang) is a formula of Japanese traditional Kampo medicine that has 9 crude drugs and provides the medicinal usage for sinusitis.
The objective of the present study is to reveal the mechanism of antibiofilm activity by Shin’iseihaito extract (SSHT).
SSHT significantly inhibited the formation of biofilm from S.
pneumoniae ATCC 49619 in dose- and time-dependent manners.
SSHT also significantly suppressed the biofilm formation by other five different cps types of S.
pneumoniae clinical isolates.
We found that the extracts of 8 out of 9 components in Shin’iseihaito had the inhibitory effects of biofilm formation, and the extract of the root of Scutellaria baicalensis had the strongest effect among the ingredients of Shin’iseihaito.
We found that the capsule of SSHT-treated S.
pneumoniae was significantly thinner than that of the untreated group and that SSHT reduced the hydrophobicity of bacterial cell surface.
Our results suggest that Shin’iseihaito may be a useful agent for the treatment of S.
pneumoniae-induced sinusitis because of the inhibition of biofilm formation of S.
pneumoniae.
American Psychological Association (APA)
Minami, Masaaki& Konishi, Toru& Takase, Hiroshi& Makino, Toshiaki. 2017. Shin’iseihaito (Xinyiqingfeitang) Suppresses the Biofilm Formation of Streptococcus pneumoniae In Vitro. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137135
Modern Language Association (MLA)
Minami, Masaaki…[et al.]. Shin’iseihaito (Xinyiqingfeitang) Suppresses the Biofilm Formation of Streptococcus pneumoniae In Vitro. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1137135
American Medical Association (AMA)
Minami, Masaaki& Konishi, Toru& Takase, Hiroshi& Makino, Toshiaki. Shin’iseihaito (Xinyiqingfeitang) Suppresses the Biofilm Formation of Streptococcus pneumoniae In Vitro. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1137135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137135