Analysis of Differentially Expressed Proteins in Mycobacterium avium-Infected Macrophages Comparing with Mycobacterium tuberculosis-Infected Macrophages
Joint Authors
Yang, Dongjun
Fu, Xin
He, Shiyi
Ning, Xueping
Ling, Min
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Mycobacterium avium (MA) belongs to the intracellular parasitic bacteria.
To better understand how MA survives within macrophages and the different pathogenic mechanisms of MA and Mycobacterium tuberculosis (MTB), tandem mass tag (TMT) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis have been used to determine the proteins which are differentially expressed in MA-infected and MTB-infected macrophages.
369 proteins were found to be differentially expressed in MA-infected cells but not in MTB-infected cells.
By using certain bioinformatics methods, we found the 369 proteins were involved in molecular function, biological process, and cellular component including binding, catalytic activity, metabolic process, cellular process, and cell part.
In addition, some identified proteins were involved in multiple signaling pathways.
These results suggest that MA probably survive within macrophages by affecting the expression of some crucial proteins.
American Psychological Association (APA)
Yang, Dongjun& Fu, Xin& He, Shiyi& Ning, Xueping& Ling, Min. 2017. Analysis of Differentially Expressed Proteins in Mycobacterium avium-Infected Macrophages Comparing with Mycobacterium tuberculosis-Infected Macrophages. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137429
Modern Language Association (MLA)
Yang, Dongjun…[et al.]. Analysis of Differentially Expressed Proteins in Mycobacterium avium-Infected Macrophages Comparing with Mycobacterium tuberculosis-Infected Macrophages. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1137429
American Medical Association (AMA)
Yang, Dongjun& Fu, Xin& He, Shiyi& Ning, Xueping& Ling, Min. Analysis of Differentially Expressed Proteins in Mycobacterium avium-Infected Macrophages Comparing with Mycobacterium tuberculosis-Infected Macrophages. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1137429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137429