Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis
Joint Authors
Wu, Yun
Li, Chan
Xia, Jianling
Xie, Ke
Zhao, Feng
Li, Tao
Zeng, Ming
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aim.
A meta-analysis was conducted to estimate the impact of connective tissue growth factor (CTGF) on outcomes in patients with digestive system cancers.
Methods.
A systemic literature survey was performed by searching the Cochrane Library and PubMed databases for articles that evaluated the impact of CTGF on outcomes in patients with digestive system cancers.
Hazard ratios and 95% confidence intervals were calculated for prognostic factors, overall and recurrence-free survival using RevMan 5.3 software.
Results.
This meta-analysis was conducted to evaluate a total of 11 studies that included 1730 patients.
The results showed that elevated CTGF expression was significantly correlated with advanced age, larger tumor size, multiple tumors, and vascular invasion.
Subgroup analysis by cancer type revealed increased risk for lymph node metastasis and advanced tumor node metastasis (TNM) stage in gastric cancer, compared with colorectal cancer.
An unfavorable effect of elevated CTGF levels on overall survival was found in patients with hepatocellular carcinoma and patients with gastric cancer, while survival was improved in colorectal cancer patients with high CTGF expression, compared to those with normal levels of CTGF.
Conclusions.
Elevated CTGF expression may be a novel biomarker for disease status and predicted survival outcomes in patients with specific digestive system cancers.
American Psychological Association (APA)
Zhao, Feng& Li, Chan& Wu, Yun& Xia, Jianling& Zeng, Ming& Li, Tao…[et al.]. 2020. Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137478
Modern Language Association (MLA)
Zhao, Feng…[et al.]. Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1137478
American Medical Association (AMA)
Zhao, Feng& Li, Chan& Wu, Yun& Xia, Jianling& Zeng, Ming& Li, Tao…[et al.]. Connective Tissue Growth Factor in Digestive System Cancers: A Review and Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1137478
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1137478