Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation

Joint Authors

Qi, Tao
Wang, Jue
Chen, Zheng
Qin, Xiao-ping
Huang, Zhang-sen
Hu, Xiao-yong
Qu, Li-jun
Zhuo, Yu-min
Chen, Guo

Source

BioMed Research International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-22

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly.

We detected the expression level of SNHG12 in PCa tissues and matched adjacent normal tissues that were collected from 85 patients.

Then, colony formation assays, MTT experiments, and flow cytometry were used to examine the effect of SNHG12 on proliferation, cell cycle distribution, and apoptosis of DU145 cells.

Further, Transwell invasion assay was utilized to assess whether SNHG12 participates in PCa cell invasion and affects the secretion of VEGF secretion in DU145 cells.

Finally, we investigated the effect of SNHG12 on tumor growth in vivo.

We found that SNHG12 promoted cell proliferation and suppressed apoptosis in PCa cells, which suggests that SNHG12 is probably a novel PCa biomarker and therapy target of PCa.

American Psychological Association (APA)

Chen, Zheng& Qi, Tao& Qin, Xiao-ping& Wang, Jue& Huang, Zhang-sen& Hu, Xiao-yong…[et al.]. 2020. Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137672

Modern Language Association (MLA)

Chen, Zheng…[et al.]. Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1137672

American Medical Association (AMA)

Chen, Zheng& Qi, Tao& Qin, Xiao-ping& Wang, Jue& Huang, Zhang-sen& Hu, Xiao-yong…[et al.]. Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1137672

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1137672