Role of Wntβ-Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer
Joint Authors
Yuan, Shengli
Tao, Fengying
Zhang, Xinglin
Zhang, Yan
Sun, Xingxing
Wu, Dapeng
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality worldwide.
To date, chemotherapy plays an important role in the treatment of CRC patients.
Multidrug resistance (MDR) is one of the major hurdles in chemotherapy for CRC, and the underlying mechanisms need to be explored.
Studies have demonstrated that Wnt/β-catenin signaling plays a critical role in oncogenesis and tumor development, and its function in inhibiting apoptosis could facilitate tumor chemoresistance.
Recent investigations have also suggested the regulatory effects of the Wnt/β-catenin signaling pathway in response to chemotherapeutic agents in CRC.
Here, we particularly focus on reviewing the evidences suggesting the mechanisms of Wnt/β-catenin signaling in the chemoresistance modulation of colorectal cancer.
American Psychological Association (APA)
Yuan, Shengli& Tao, Fengying& Zhang, Xinglin& Zhang, Yan& Sun, Xingxing& Wu, Dapeng. 2020. Role of Wntβ-Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138099
Modern Language Association (MLA)
Yuan, Shengli…[et al.]. Role of Wntβ-Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138099
American Medical Association (AMA)
Yuan, Shengli& Tao, Fengying& Zhang, Xinglin& Zhang, Yan& Sun, Xingxing& Wu, Dapeng. Role of Wntβ-Catenin Signaling in the Chemoresistance Modulation of Colorectal Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138099
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138099