Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression
Joint Authors
Zhou, Fuling
Huang, Tian-he
Wei, Yongchang
Pan, Yunbao
He, Chenyan
Hui, Lingyun
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Depression is the most common psychiatric disorder among cancer patients.
Studies have not only highlighted that leptin and its receptor (LepRb) are independent poor prognostic factors in gastric cancer (GC) patients but also shown that the leptin-LepRb is necessary for antidepressant-like behaviors.
In this study, we examined the serum and tissue leptin-LepRb expression in GC patients.
Enzyme-linked immunosorbent assay showed that depressive GC patients had significantly higher serum leptin-LepRb than healthy donors.
Leptin-LepRb levels in GC tissues were also significantly higher than in matched paracarcinoma tissues using real-time RT-PCR.
Moreover, we observed that both serum and tissue leptin-LepRb were significantly higher in depressive GC patients than those in nondepressive GC patients.
Further, the patients with high tumor stage tend to have higher leptin-LepRb mRNA levels than that with low tumor stage.
Together, our findings suggest that leptin-LepRb plays an important role in the pathogenesis and depression in GC.
Leptin-LepRb therefore could be a potential diagnostic marker and therapeutic target in GC patients with depression.
American Psychological Association (APA)
Pan, Yunbao& Zhou, Fuling& He, Chenyan& Hui, Lingyun& Huang, Tian-he& Wei, Yongchang. 2017. Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138109
Modern Language Association (MLA)
Pan, Yunbao…[et al.]. Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1138109
American Medical Association (AMA)
Pan, Yunbao& Zhou, Fuling& He, Chenyan& Hui, Lingyun& Huang, Tian-he& Wei, Yongchang. Leptin-LepRb Expressed in Gastric Cancer Patients and Related to Cancer-Related Depression. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1138109
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138109