The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer
Joint Authors
Jiao, Yan
Li, Yanqing
Wang, Ruobing
Ye, Siyang
Pan, Guoqiang
Qin, Shanshan
Hua, Fang
Liu, Yahui
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Liver cancer is a devastating disease for humans with poor prognosis.
Although the survival rate of patients with liver cancer has improved in the past decades, the recurrence and metastasis of liver cancer are still obstacles for us.
Inositol polyphosphate-5-phosphatase K (INPP5K) belongs to the family of phosphoinositide 5-phosphatases (PI 5-phosphatases), which have been reported to be associated with cell migration, polarity, adhesion, and cell invasion, especially in cancers.
However, there have been few studies on the correlation of INPP5K and liver cancer.
In this study, we explored the prognostic significance of INPP5K in liver cancer through bioinformatics analysis of data collected from The Cancer Genome Atlas (TCGA) database.
Chi-square and Fisher exact tests were used to evaluate the relationship between INPP5K expression and clinical characteristics.
Our results showed that low INPP5K expression was correlated with poor outcomes in liver cancer patients.
Univariate and multivariate Cox analyses demonstrated that low INPP5K mRNA expression played a significant role in shortening overall survival (OS) and relapse-free survival (RFS), which might serve as the useful biomarker and prognostic factor for liver cancer.
In conclusion, low INPP5K mRNA expression is an independent risk factor for poor prognosis in liver cancer.
American Psychological Association (APA)
Wang, Ruobing& Jiao, Yan& Li, Yanqing& Ye, Siyang& Pan, Guoqiang& Qin, Shanshan…[et al.]. 2020. The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138151
Modern Language Association (MLA)
Wang, Ruobing…[et al.]. The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1138151
American Medical Association (AMA)
Wang, Ruobing& Jiao, Yan& Li, Yanqing& Ye, Siyang& Pan, Guoqiang& Qin, Shanshan…[et al.]. The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1138151
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138151