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The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence
Joint Authors
Assefa, Brhane Teklebrhan
Wondafrash, Dawit Zewdu
Gidey, Meles Tekie
Tafere, Gebrehiwot Gebremedhin
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-18
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Alzheimer’s disease is a multifactorial neurodegenerative disease characterized by progressive cognitive dysfunction.
It is the most common form of dementia.
The pathologic hallmarks of the disease include extracellular amyloid plaque, intracellular neurofibrillary tangles, and oxidative stress, to mention some of them.
Despite remarkable progress in the understanding of the pathogenesis of the disease, drugs for cure or disease-modifying therapy remain somewhere in the distance.
From recent time, the signaling molecule AMPK is gaining enormous attention in the AD drug research.
AMPK is a master regulator of cellular energy metabolism, and recent pieces of evidence show that perturbation of its function is highly ascribed in the pathology of AD.
Several drugs are known to activate AMPK, but their effect in AD remains to be controversial.
In this review, the current shreds of evidence on the effect of AMPK activators in Aβ accumulation, tau aggregation, and oxidative stress are addressed.
Positive and negative effects are reported with regard to Aβ and tauopathy but only positive in oxidative stress.
We also tried to dissect the molecular interplays where the bewildering effects arise from.
American Psychological Association (APA)
Assefa, Brhane Teklebrhan& Tafere, Gebrehiwot Gebremedhin& Wondafrash, Dawit Zewdu& Gidey, Meles Tekie. 2020. The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence. BioMed Research International،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1138349
Modern Language Association (MLA)
Assefa, Brhane Teklebrhan…[et al.]. The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence. BioMed Research International No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1138349
American Medical Association (AMA)
Assefa, Brhane Teklebrhan& Tafere, Gebrehiwot Gebremedhin& Wondafrash, Dawit Zewdu& Gidey, Meles Tekie. The Bewildering Effect of AMPK Activators in Alzheimer’s Disease: Review of the Current Evidence. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1138349
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1138349