Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress

Joint Authors

Chávez, Edmundo
Buelna-Chontal, Mabel
Macías-López, Arturo
Hernández-Esquivel, Luz
Correa, Francisco
Pavón, Natalia

Source

Biochemistry Research International

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-22

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Chemistry

Abstract EN

Mitochondrial permeability transition is characterized by the opening of a transmembranal pore that switches membrane permeability from specific to nonspecific.

This structure allows the free traffic of ions, metabolites, and water across the mitochondrial inner membrane.

The opening of the permeability transition pore is triggered by oxidative stress along with calcium overload.

In this work, we explored if oxidative stress is a consequence, rather than an effector of the pore opening, by evaluating the interaction of agaric acid with the adenine nucleotide translocase, a structural component of the permeability transition pore.

We found that agaric acid induces transition pore opening, increases the generation of oxygen-derived reactive species, augments the oxidation of unsaturated fatty acids in the membrane, and promotes the detachment of cytochrome c from the inner membrane.

The effect of agaric acid was inhibited by the antioxidant tamoxifen in association with decreased binding of the thiol reagent eosin-3 maleimide to the adenine nucleotide translocase.

We conclude that agaric acid promotes the opening of the pore, increasing ROS production that exerts oxidative modification of critical thiols in the adenine nucleotide translocase.

American Psychological Association (APA)

Chávez, Edmundo& Buelna-Chontal, Mabel& Macías-López, Arturo& Hernández-Esquivel, Luz& Correa, Francisco& Pavón, Natalia. 2020. Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress. Biochemistry Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138453

Modern Language Association (MLA)

Chávez, Edmundo…[et al.]. Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress. Biochemistry Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1138453

American Medical Association (AMA)

Chávez, Edmundo& Buelna-Chontal, Mabel& Macías-López, Arturo& Hernández-Esquivel, Luz& Correa, Francisco& Pavón, Natalia. Interaction of Agaric Acid with the Adenine Nucleotide Translocase Induces Mitochondrial Oxidative Stress. Biochemistry Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1138453

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1138453