Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery
Joint Authors
Hai, Nguyen Dai
Nguyen, Thanh Luan
Nguyen, Thi Hiep
Nguyen, Cuu Khoa
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Heparin (Hep) conjugated to poly (amidoamine) dendrimer G3.5 (P) via redox-sensitive disulfide bond (P-SS-Hep) was studied.
The redox and pH dual-responsive nanocarriers were prepared by a simple method that minimized many complex steps as previous studies.
The functional characterization of G3.5 coated Hep was investigated by the proton nuclear magnetic resonance spectroscopy.
The size and formation were characterized by the dynamic light scattering, zeta potential, and transmission electron microscopy.
P-SS-Hep was spherical in shape with average diameter about 11 nm loaded with more than 20% letrozole.
This drug carrier could not only eliminate toxicity to cells and improve the drugs solubility but also increase biocompatibility of the system under reductive environment of glutathione.
In particular, P-SS-Hep could enhance the effectiveness of cancer therapy after removing Hep from the surface.
These results demonstrated that the P-SS-Hep conjugates could be a promising candidate as redox and pH responsive nanocarriers for cancer chemotherapy.
American Psychological Association (APA)
Nguyen, Thanh Luan& Nguyen, Thi Hiep& Nguyen, Cuu Khoa& Hai, Nguyen Dai. 2017. Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139169
Modern Language Association (MLA)
Nguyen, Thanh Luan…[et al.]. Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1139169
American Medical Association (AMA)
Nguyen, Thanh Luan& Nguyen, Thi Hiep& Nguyen, Cuu Khoa& Hai, Nguyen Dai. Redox and pH Responsive Poly (Amidoamine) Dendrimer-Heparin Conjugates via Disulfide Linkages for Letrozole Delivery. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1139169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139169