Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells
Joint Authors
Czajkowska, Anna
Gornowicz, Agnieszka
Pawłowska, Natalia
Czarnomysy, Robert
Nazaruk, Jolanta
Szymanowski, Wojciech
Bielawska, Anna
Bielawski, Krzysztof
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Many studies have shown that naturally occurring compounds may support prevention and treatment of various diseases, including cancer.
Pharmacological investigations revealed a wide spectrum of Nigella sativa biological activities.
Combining natural compounds together with synthetic drugs may increase the anticancer activity and limit severe side effects of such a treatment and may be an alternative to monotherapy.
The aim of the study was to evaluate the cytotoxic and proapoptotic effects of a novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative and its effect in combination with Nigella sativa seed oil or extract in human gastric cancer cells (AGS).
Etoposide was used as a reference.
Our studies proved that combination strategy based on novel octahydropyrazino[2,1-a:5,4-a′]diisoquinoline derivative (OM-90) with Nigella sativa seed oil or extract represents the strongest efficacy in AGS cancer cells as compared to monotherapy and combined treatment with Nigella sativa seed oil or extract together with etoposide.
Such a combination also leads to the activation of mitochondrial pathway, which plays a significant role in molecular mechanism of induction of apoptosis by these compounds.
American Psychological Association (APA)
Czajkowska, Anna& Gornowicz, Agnieszka& Pawłowska, Natalia& Czarnomysy, Robert& Nazaruk, Jolanta& Szymanowski, Wojciech…[et al.]. 2017. Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells. BioMed Research International،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139359
Modern Language Association (MLA)
Czajkowska, Anna…[et al.]. Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells. BioMed Research International No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1139359
American Medical Association (AMA)
Czajkowska, Anna& Gornowicz, Agnieszka& Pawłowska, Natalia& Czarnomysy, Robert& Nazaruk, Jolanta& Szymanowski, Wojciech…[et al.]. Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a′]diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1139359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139359