Glycyrrhizin Protects Rats from Sepsis by Blocking HMGB1 Signaling
Joint Authors
Zhao, Feng
Fang, Yong
Deng, Shuixiang
Li, Xiantao
Zhou, Yun
Gong, Ye
Zhu, Hechen
Wang, Wei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
HMGB1 acts as an important inflammatory mediator and is a potential therapeutic target for sepsis.
Glycyrrhizin (GL), a natural triterpene glycoside derived from licorice, has been demonstrated to inhibit HMGB1 activity.
The aim of this study is to explore how GL affects the HMGB1 signaling in sepsis.
Methods.
We used a CLP model of sepsis and in vitro LPS or HMGB1-treated NR8383 cells to examine the effects of GL on expression of HMGB1 and proinflammatory cytokines.
Furthermore, we explored the effect of GL on interactions between HMGB1 and RAGE or TLR4 and the activations of NF-κB and MAPKs.
Results.
GL significantly decreased mortality and reduced serum levels of HMGB1 in vivo.
GL also attenuated the release and expression of HMGB1 and proinflammatory cytokines.
Direct stimulation by HMGB1 elevated the release of proinflammatory cytokines faster than LPS did and it was also inhibited by GL.
Furthermore, GL blocked the interaction of HMGB1 with RAGE and TLR4 and suppressed the downstream MAPKs/NF-κB signaling pathway.
Conclusion.
GL may protect rats against sepsis by blocking the interaction of HMGB1 with cell surface receptors and HMGB1-mediated inflammatory responses.
American Psychological Association (APA)
Zhao, Feng& Fang, Yong& Deng, Shuixiang& Li, Xiantao& Zhou, Yun& Gong, Ye…[et al.]. 2017. Glycyrrhizin Protects Rats from Sepsis by Blocking HMGB1 Signaling. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139704
Modern Language Association (MLA)
Zhao, Feng…[et al.]. Glycyrrhizin Protects Rats from Sepsis by Blocking HMGB1 Signaling. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1139704
American Medical Association (AMA)
Zhao, Feng& Fang, Yong& Deng, Shuixiang& Li, Xiantao& Zhou, Yun& Gong, Ye…[et al.]. Glycyrrhizin Protects Rats from Sepsis by Blocking HMGB1 Signaling. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1139704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1139704