High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26
Joint Authors
Mitran, Bogdan
Orlova, Anna
Tolmachev, Vladimir
Thisgaard, Helge
Rosenström, Ulrika
Dam, Johan Hygum
Larhed, Mats
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
High gastrin releasing peptide receptor (GRPR) expression is associated with numerous cancers including prostate and breast cancer.
The aim of the current study was to develop a 55Co-labeled PET agent based on GRPR antagonist RM26 for visualization of GRPR-expressing tumors.
Labeling with 57Co and 55Co, stability, binding specificity, and in vitro and in vivo characteristics of 57Co-NOTA-PEG2-RM26 were studied.
NOTA-PEG2-RM26 was successfully radiolabeled with 57Co and 55Co with high yields and demonstrated high stability.
The radiopeptide showed retained binding specificity to GRPR in vitro and in vivo.
57Co-NOTA-PEG2-RM26 biodistribution in mice was characterized by rapid clearance of radioactivity from blood and normal non-GRPR-expressing organs and low hepatic uptake.
The clearance was predominantly renal with a low degree of radioactivity reabsorption.
Tumor-to-blood ratios were approximately 200 (3 h pi) and 1000 (24 h pi).
The favorable biodistribution of cobalt-labeled NOTA-PEG2-RM26 translated into high contrast preclinical PET/CT (using 55Co) and SPECT/CT (using 57Co) images of PC-3 xenografts.
The initial biological results suggest that 55Co-NOTA-PEG2-RM26 is a promising tracer for PET visualization of GRPR-expressing tumors.
American Psychological Association (APA)
Mitran, Bogdan& Thisgaard, Helge& Rosenström, Ulrika& Dam, Johan Hygum& Larhed, Mats& Tolmachev, Vladimir…[et al.]. 2017. High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141819
Modern Language Association (MLA)
Mitran, Bogdan…[et al.]. High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141819
American Medical Association (AMA)
Mitran, Bogdan& Thisgaard, Helge& Rosenström, Ulrika& Dam, Johan Hygum& Larhed, Mats& Tolmachev, Vladimir…[et al.]. High Contrast PET Imaging of GRPR Expression in Prostate Cancer Using Cobalt-Labeled Bombesin Antagonist RM26. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141819