Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry
Joint Authors
Jalkanen, Sirpa
Roivainen, Anne
Li, Xiang-Guo
Airaksinen, Anu J.
Helariutta, Kerttuli
Hellberg, Sanna
Liljenbäck, Heidi
Knuuti, Juhani
Saraste, Antti
Autio, Anu
Virtanen, Helena
Silvola, Johanna M. U.
Siitonen, Riikka
Ståhle, Mia
Käkelä, Meeri
Tolvanen, Tuula
Veres, Tibor Z.
Source
Contrast Media & Molecular Imaging
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is a ligand of inflammation-inducible vascular adhesion protein-1 (VAP-1).
We compared 68Ga-DOTA- and 18F-fluorodeoxyribose- (FDR-) labeled Siglec-9 motif peptides for PET imaging of inflammation.
Methods.
Firstly, we examined 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9 in rats with skin/muscle inflammation.
We then studied 18F-FDR-Siglec-9 for the detection of inflamed atherosclerotic plaques in mice and compared it with previous 68Ga-DOTA-Siglec-9 results.
Lastly, we estimated human radiation dosimetry from the rat data.
Results.
In rats, 68Ga-DOTA-Siglec-9 (SUV, 0.88±0.087) and 18F-FDR-Siglec-9 (SUV, 0.77±0.22) showed comparable (P=0.29) imaging of inflammation.
In atherosclerotic mice, 18F-FDR-Siglec-9 detected inflamed plaques with a target-to-background ratio (1.6±0.078) similar to previously tested 68Ga-DOTA-Siglec-9 (P=0.35).
Human effective dose estimates for 68Ga-DOTA-Siglec-9 and 18F-FDR-Siglec-9 were 0.024 and 0.022 mSv/MBq, respectively.
Conclusion.
Both tracers are suitable for PET imaging of inflammation.
The easier production and lower cost of 68Ga-DOTA-Siglec-9 present advantages over 18F-FDR-Siglec-9, indicating it as a primary choice for clinical studies.
American Psychological Association (APA)
Virtanen, Helena& Silvola, Johanna M. U.& Autio, Anu& Li, Xiang-Guo& Liljenbäck, Heidi& Hellberg, Sanna…[et al.]. 2017. Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry. Contrast Media & Molecular Imaging،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141845
Modern Language Association (MLA)
Virtanen, Helena…[et al.]. Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry. Contrast Media & Molecular Imaging No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1141845
American Medical Association (AMA)
Virtanen, Helena& Silvola, Johanna M. U.& Autio, Anu& Li, Xiang-Guo& Liljenbäck, Heidi& Hellberg, Sanna…[et al.]. Comparison of 68Ga-DOTA-Siglec-9 and 18F-Fluorodeoxyribose-Siglec-9: Inflammation Imaging and Radiation Dosimetry. Contrast Media & Molecular Imaging. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1141845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1141845