Curvature-Induced Spatial Ordering of Composition in Lipid Membranes
Joint Authors
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Phase segregation of membranal components, such as proteins, lipids, and cholesterols, leads to the formation of aggregates or domains that are rich in specific constituents.
This process is important in the interaction of the cell with its surroundings and in determining the cell’s behavior and fate.
Motivated by published experiments on curvature-modulated phase separation in lipid membranes, we formulate a mathematical model aiming at studying the spatial ordering of composition in a two-component biomembrane that is subjected to a prescribed (imposed) geometry.
Based on this model, we identified key nondimensional quantities that govern the biomembrane response and performed numerical simulations to quantitatively explore their influence.
We reproduce published experimental observations and extend them to surfaces with geometric features (imposed geometry) and lipid phases beyond those used in the experiments.
In addition, we demonstrate the possibility for curvature-modulated phase separation above the critical temperature and propose a systematic procedure to determine which mechanism, the difference in bending stiffness or difference in spontaneous curvatures of the two phases, dominates the coupling between shape and composition.
American Psychological Association (APA)
Katz, Shimrit& Givli, Sefi. 2017. Curvature-Induced Spatial Ordering of Composition in Lipid Membranes. Computational and Mathematical Methods in Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1142285
Modern Language Association (MLA)
Katz, Shimrit& Givli, Sefi. Curvature-Induced Spatial Ordering of Composition in Lipid Membranes. Computational and Mathematical Methods in Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1142285
American Medical Association (AMA)
Katz, Shimrit& Givli, Sefi. Curvature-Induced Spatial Ordering of Composition in Lipid Membranes. Computational and Mathematical Methods in Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1142285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142285