Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness
Joint Authors
Lauria, Mario
Marchetti, Luca
Siena, Emilio
Maffione, Denise
Pacchiani, Nicola
Medini, Duccio
Priami, Corrado
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Systems biology has been recently applied to vaccinology to better understand immunological responses to the influenza vaccine.
Particular attention has been paid to the identification of early signatures capable of predicting vaccine immunogenicity.
Building from previous studies, we employed a recently established algorithm for signature-based clustering of expression profiles, SCUDO, to provide new insights into why blood-derived transcriptome biomarkers often fail to predict the seroresponse to the influenza virus vaccination.
Specifically, preexisting immunity against one or more vaccine antigens, which was found to negatively affect the seroresponse, was identified as a confounding factor able to decouple early transcriptome from later antibody responses, resulting in the degradation of a biomarker predictive power.
Finally, the broadly accepted definition of seroresponse to influenza virus vaccine, represented by the maximum response across the vaccine-targeted strains, was compared to a composite measure integrating the responses against all strains.
This analysis revealed that composite measures provide a more accurate assessment of the seroresponse to multicomponent influenza vaccines.
American Psychological Association (APA)
Marchetti, Luca& Siena, Emilio& Lauria, Mario& Maffione, Denise& Pacchiani, Nicola& Priami, Corrado…[et al.]. 2017. Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness. Complexity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142674
Modern Language Association (MLA)
Marchetti, Luca…[et al.]. Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness. Complexity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1142674
American Medical Association (AMA)
Marchetti, Luca& Siena, Emilio& Lauria, Mario& Maffione, Denise& Pacchiani, Nicola& Priami, Corrado…[et al.]. Exploring the Limitations of Peripheral Blood Transcriptional Biomarkers in Predicting Influenza Vaccine Responsiveness. Complexity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1142674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1142674