ALK-Positive Squamous Cell Carcinoma Dramatically Responded to Alectinib
Joint Authors
Sagawa, Ray
Ohba, Takehiko
Ito, Eisaku
Isogai, Susumu
Source
Case Reports in Oncological Medicine
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-18
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Anaplastic lymphoma kinase (ALK) rearrangement is usually observed in patients with adenocarcinoma.
Herein, we report a case of squamous cell carcinoma (SCC) with ALK rearrangement treated with alectinib.
The patient was a 73-year-old woman without a smoking history.
She consulted us with nonproductive cough and loss of appetite.
Computed tomography scan revealed a mass in the left lower lobe of the lung.
According to the pathological examinations, we diagnosed the tumor as SCC.
Because the patient had never smoked, we searched for driver mutations and found that the tumor harbored ALK rearrangement.
We began treatment with alectinib, and the tumor remarkably reduced in volume.
No severe adverse events were observed.
Although there are only few reports of SCC with ALK rearrangement, this case implies that clinicians should consider searching for driver mutations in patients with SCC when there are atypical findings or characteristics.
American Psychological Association (APA)
Sagawa, Ray& Ohba, Takehiko& Ito, Eisaku& Isogai, Susumu. 2018. ALK-Positive Squamous Cell Carcinoma Dramatically Responded to Alectinib. Case Reports in Oncological Medicine،Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1146352
Modern Language Association (MLA)
Sagawa, Ray…[et al.]. ALK-Positive Squamous Cell Carcinoma Dramatically Responded to Alectinib. Case Reports in Oncological Medicine No. 2018 (2018), pp.1-3.
https://search.emarefa.net/detail/BIM-1146352
American Medical Association (AMA)
Sagawa, Ray& Ohba, Takehiko& Ito, Eisaku& Isogai, Susumu. ALK-Positive Squamous Cell Carcinoma Dramatically Responded to Alectinib. Case Reports in Oncological Medicine. 2018. Vol. 2018, no. 2018, pp.1-3.
https://search.emarefa.net/detail/BIM-1146352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1146352