Efficacy of the Combination of rhBMP-2 with Bone Marrow Aspirate Concentrate in Mandibular Defect Reconstruction after a Pindborg Tumor Resection

Abstract EN

Recombinant human bone morphogenetic protein-2 (rhBMP-2) is an osteoinductive growth factor used in oral and maxillofacial surgery.

It offers a feasible alternative for various regenerative procedures, including reconstruction of mandibular defects.

In this study, we report a case of a large Pindborg tumor involving the left mandible.

The treatment consisted of surgical resection, followed by off-label use of rhBMP-2 in addition to bone marrow aspirate concentrate, together with an allograft in a titanium mesh.

The patient was rehabilitated with dental implants, and a good clinical outcome was achieved.

We found no evidence of bone resorption or complications in both clinical and radiographic evaluations during the one-year follow-up period.

In conclusion, we have demonstrated the efficacy of using rhBMP-2 combined with bone marrow aspirate concentrate, and an allograft with a titanium mesh, for the reconstruction of long mandibular bone defects.

Not only is this combination feasible, but it also has the advantages of lower morbidity and cost.