From ACTH-Dependent to ACTH-Independent Cushing’s Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells
Joint Authors
Ramírez-Rentería, Claudia
Espinosa, Etual
Mercado, Moisés
Espinosa-de-los-Monteros, Ana-Laura
Marrero-Rodriguez, Daniel
Castellanos, Guillermo
Arreola-Rosales, Rocio
Montoya-Martinez, Guillermo
Taniguchi-Ponciano, Keiko
Briseño-Diaz, Paola
Padilla-Cristerna, Mayte-Lizeth
Figueroa-Corona, Maria-del-Pilar
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-05-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Context.
Truly, mixed corticomedullary adrenal tumors (MCATs) may not come from colliding tumors but from a single stem cell.
Objective.
To report the immunohistochemical and molecular evaluation of a patient with ectopic ACTH syndrome (EAS) from a MCAT which has single cells with features of both 96 medullary and cortical differentiation.
Case Description and Methods.
A 16-year-old woman presented with severe EAS and a large right MCAT composed of ACTH-secreting cells resembling pheochromocytoma and another lineage similar to adrenal carcinoma.
Immunohistochemistry (IHC) showed positivity for medullary (ACTH, chromogranin A, synaptophysin, and PS-100) and epithelial components (inhibin, melan-A, and calretinin).
Embryonic stem cell markers were evaluated using RT/PCR and immunofluorescence.
After initial surgery, the tumor recurred shifting to rapidly progressive ACTH-independent liver metastasis.
Results.
Histopathology and IHC revealed two distinct and intermingled cellular patterns, while some cells immunostained for both medullary and cortical markers.
Demonstration of all stem cell biomarkers by RT/PCR and immunofluorescence was predominantly localized to the nucleus, whereas SOX2 immunoreactivity was evident in the cytoplasm as well.
Conclusion.
The expression of cancer stem cell biomarkers points towards the involvement of primitive embryonic cells as the origin of this neoplasm and maybe to the clinically aggressive and biochemically changing behavior.
American Psychological Association (APA)
Ramírez-Rentería, Claudia& Espinosa-de-los-Monteros, Ana-Laura& Espinosa, Etual& Marrero-Rodriguez, Daniel& Castellanos, Guillermo& Arreola-Rosales, Rocio…[et al.]. 2020. From ACTH-Dependent to ACTH-Independent Cushing’s Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1147024
Modern Language Association (MLA)
Ramírez-Rentería, Claudia…[et al.]. From ACTH-Dependent to ACTH-Independent Cushing’s Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells. Case Reports in Endocrinology No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1147024
American Medical Association (AMA)
Ramírez-Rentería, Claudia& Espinosa-de-los-Monteros, Ana-Laura& Espinosa, Etual& Marrero-Rodriguez, Daniel& Castellanos, Guillermo& Arreola-Rosales, Rocio…[et al.]. From ACTH-Dependent to ACTH-Independent Cushing’s Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1147024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147024