The Unusual Late-Onset Graves’ Disease following Hashimoto’s Related Hypothyroidism: A Case Report and Literature Review
Joint Authors
Sukik, Aseel
Mohamed, Sara
Habib, Mhd-Baraa
Sardar, Sundus
Tanous, Bashar
Tahtouh, Raad
Mohamed, Mouhand F. H.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
The shift of Graves’ disease (GD) to Hashimoto’s disease- (HD-) related hypothyroidism is well established.
However, the opposite is rare.
This is likely to the loss of critical thyroid mass available for stimulation by thyroid hormone receptor stimulating antibody, making this shift unusual.
Herein, we report a young lady with a late shift from HD into GD and present a scoping literature review.
Case presentation.
We report a twenty-five-year-old lady with a sixteen-year-history of Hashimoto’s-related hypothyroidism stable on levothyroxine.
While following in the clinic, she started developing thyrotoxic symptoms in the form of anxiety, weight loss, and palpitation.
Physical examination was remarkable for mild exophthalmos.
The thyroid function test confirmed hyperthyroidism.
Levothyroxine-induced hyperthyroidism was initially suspected; however, the symptoms did not improve despite reducing and stopping levothyroxine.
Subsequent workup confirmed the diagnosis of GD.
Discussion and Conclusion.
This case highlights a unique association that has significant diagnostic and management implications.
This shift should be considered when hyperthyroidism persists despite reducing or stopping levothyroxine.
The diagnosis is made utilizing antibody titers and radioiodine update scan.
While the management depends on the disease’s stage and the treating physician preference, antithyroid agents can be used initially.
Following up these patients is essential as the shift can be transient.
American Psychological Association (APA)
Sukik, Aseel& Mohamed, Sara& Habib, Mhd-Baraa& Sardar, Sundus& Tanous, Bashar& Tahtouh, Raad…[et al.]. 2020. The Unusual Late-Onset Graves’ Disease following Hashimoto’s Related Hypothyroidism: A Case Report and Literature Review. Case Reports in Endocrinology،Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147039
Modern Language Association (MLA)
Sukik, Aseel…[et al.]. The Unusual Late-Onset Graves’ Disease following Hashimoto’s Related Hypothyroidism: A Case Report and Literature Review. Case Reports in Endocrinology No. 2020 (2020), pp.1-4.
https://search.emarefa.net/detail/BIM-1147039
American Medical Association (AMA)
Sukik, Aseel& Mohamed, Sara& Habib, Mhd-Baraa& Sardar, Sundus& Tanous, Bashar& Tahtouh, Raad…[et al.]. The Unusual Late-Onset Graves’ Disease following Hashimoto’s Related Hypothyroidism: A Case Report and Literature Review. Case Reports in Endocrinology. 2020. Vol. 2020, no. 2020, pp.1-4.
https://search.emarefa.net/detail/BIM-1147039
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147039