Differential Effects of Awake Glioma Surgery in “Critical” Language Areas on Cognition: 4 Case Studies
Joint Authors
Mariën, Peter
Satoer, Djaina
De Witte, Elke
Smits, Marion
Visch-Brink, Evy
Vincent, Arnaud J.
Bastiaanse, Roelien
Source
Case Reports in Neurological Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Awake surgery with electrocorticosubcortical stimulation is the golden standard treatment for gliomas in eloquent areas.
Preoperatively, mostly mild cognitive disturbances are observed with postoperative deterioration.
We describe pre- and postoperative profiles of 4 patients (P1–P4) with gliomas in “critical” language areas (“Broca,” “Wernicke,” and the arcuate fasciculus) undergoing awake surgery to get insight into the underlying mechanism of neuroplasticity.
Neuropsychological examination was carried out preoperatively (at T1) and postoperatively (at T2, T3).
At T1, cognition of P1 was intact and remained stable.
P2 had impairments in all cognitive domains at T1 with further deterioration at T2 and T3.
At T1, P3 had impairments in memory and executive functions followed by stable recovery.
P4 was intact at T1, followed by a decline in a language test at T2 and recovery at T3.
Intraoperatively, in all patients language positive sites were identified.
Patients with gliomas in “critical” language areas do not necessarily present cognitive disturbances.
Surgery can either improve or deteriorate (existing) cognitive impairments.
Several factors may underlie the plastic potential of the brain, for example, corticosubcortical networks and tumor histopathology.
Our findings illustrate the complexity of the underlying mechanism of neural plasticity and provide further support for a “hodotopical” viewpoint.
American Psychological Association (APA)
Satoer, Djaina& De Witte, Elke& Smits, Marion& Bastiaanse, Roelien& Vincent, Arnaud J.& Mariën, Peter…[et al.]. 2017. Differential Effects of Awake Glioma Surgery in “Critical” Language Areas on Cognition: 4 Case Studies. Case Reports in Neurological Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1147178
Modern Language Association (MLA)
Satoer, Djaina…[et al.]. Differential Effects of Awake Glioma Surgery in “Critical” Language Areas on Cognition: 4 Case Studies. Case Reports in Neurological Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1147178
American Medical Association (AMA)
Satoer, Djaina& De Witte, Elke& Smits, Marion& Bastiaanse, Roelien& Vincent, Arnaud J.& Mariën, Peter…[et al.]. Differential Effects of Awake Glioma Surgery in “Critical” Language Areas on Cognition: 4 Case Studies. Case Reports in Neurological Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1147178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147178