Serum Expression of β-Catenin Is a Potential Detection Marker in Patients with Colorectal Cancer
Joint Authors
Li, Shue
Huang, Mao
Liu, Qiao
Wang, Ding
Wu, Rui
Zhang, Xiuyu
Chen, Weixian
Duan, Liang
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Object.
To investigate the correlation between the level of serum β-catenin and the disease progression of colorectal polyp (CRP) and colorectal cancer (CRC) and find its potential diagnostic value.
Methods.
A total of 327 clinical serum samples and their electronic medical records were collected.
Detecting by enzyme-linked immunosorbent assay (ELISA), the correlations of serum β-catenin with tumor marker carcinoembryonic antigen (CEA) and CRC clinicopathological parameters and the receiver operating characteristic (ROC) curve were analyzed.
Results.
Serum β-catenin levels in the CRP and CRC patients were significantly higher than those in the healthy control (HC) group (P<0.05 and P<0.001).
Compared with CRP, serum β-catenin level in CRC was also increased (P<0.05).
However, there was no significant difference in gender, age, location, tumor size, Dukes staging, or metastasis (P>0.05) between serum β-catenin and clinical parameters of CRC.
There was no correlation between serum β-catenin levels and CEA in CRC patients (P=0.14).
ROC curve analysis showed that serum β-catenin possessed the maximum diagnostic efficiency in CRP (AUC=0.73, P<0.05) with 86.41% sensitivity and 51.56% specificity.
β-Catenin combined with CEA had the highest diagnostic efficiency (AUC=0.88, P<0.05) with 81.88% sensitivity and 73.44% specificity.
With CRC patients from CRP patients, ROC analysis of the combining detection (AUC=0.70, P<0.05) had the 70% sensitivity and 84.5% specificity.
Conclusion.
The serum β-catenin levels are gradually increased in CRP and CRC, while there is no correlation between its levels and CRC disease process.
Single serum β-catenin or combined CEA would be one of the potential candidate biomarkers for colorectal disease diagnosis.
American Psychological Association (APA)
Li, Shue& Huang, Mao& Liu, Qiao& Wang, Ding& Wu, Rui& Zhang, Xiuyu…[et al.]. 2019. Serum Expression of β-Catenin Is a Potential Detection Marker in Patients with Colorectal Cancer. Disease Markers،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147318
Modern Language Association (MLA)
Li, Shue…[et al.]. Serum Expression of β-Catenin Is a Potential Detection Marker in Patients with Colorectal Cancer. Disease Markers No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1147318
American Medical Association (AMA)
Li, Shue& Huang, Mao& Liu, Qiao& Wang, Ding& Wu, Rui& Zhang, Xiuyu…[et al.]. Serum Expression of β-Catenin Is a Potential Detection Marker in Patients with Colorectal Cancer. Disease Markers. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1147318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147318