Tumors Sharply Increased after Ceasing Pazopanib Therapy for a Patient with Advanced Uterine Leiomyosarcoma: Experience of Tumor Flare
Joint Authors
Tanigawa, Terumi
Morisaki, Shintaro
Fukuda, Hisanobu
Yoshimura, Shuichiro
Nakajima, Hisayoshi
Kotera, Kohei
Source
Case Reports in Obstetrics and Gynecology
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Pazopanib has activity in patients with soft-tissue sarcoma.
We report an advanced uterine leiomyosarcoma case that suddenly worsened after cessation of pazopanib therapy.
A 47-year-old woman had a primary uterine leiomyosarcoma tumor and multiple lung metastases, which progressed during her initial treatment.
In subsequent treatment with pazopanib for 3 months, the sum of her tumor diameters after cessation sharply increased for two weeks.
Symptoms such as dyspnea suddenly worsened also.
She died of the disease one month after cessation of pazopanib therapy.
Given the poor prognosis of recurrent uterine leiomyosarcoma and the rapid tumor enlargement after ending pazopanib therapy, control of this disease is especially important.
Therefore, the decision to discontinue pazopanib therapy requires careful consideration.
American Psychological Association (APA)
Tanigawa, Terumi& Morisaki, Shintaro& Fukuda, Hisanobu& Yoshimura, Shuichiro& Nakajima, Hisayoshi& Kotera, Kohei. 2017. Tumors Sharply Increased after Ceasing Pazopanib Therapy for a Patient with Advanced Uterine Leiomyosarcoma: Experience of Tumor Flare. Case Reports in Obstetrics and Gynecology،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147381
Modern Language Association (MLA)
Tanigawa, Terumi…[et al.]. Tumors Sharply Increased after Ceasing Pazopanib Therapy for a Patient with Advanced Uterine Leiomyosarcoma: Experience of Tumor Flare. Case Reports in Obstetrics and Gynecology No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1147381
American Medical Association (AMA)
Tanigawa, Terumi& Morisaki, Shintaro& Fukuda, Hisanobu& Yoshimura, Shuichiro& Nakajima, Hisayoshi& Kotera, Kohei. Tumors Sharply Increased after Ceasing Pazopanib Therapy for a Patient with Advanced Uterine Leiomyosarcoma: Experience of Tumor Flare. Case Reports in Obstetrics and Gynecology. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1147381
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147381