Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review
Joint Authors
Valliani, Salimah
Ali, Mir
Mahmoo, Omar
Hinduja, Sanjay
Chen, Calvin K.
Damon, Lloyd
Abdulhaq, Haifaa
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-12-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Primary plasma cell leukemia (pPCL) is an uncommon disease.
IgM multiple myeloma (MM) is an infrequent subtype that accounts for less than 1 percent of MM cases.
IgM pPCL is quite rare with only a few cases published to date.
We describe a case of a patient with IgM pPCL who initially presented with hyperviscosity syndrome requiring urgent plasma exchange.
His bone marrow biopsy demonstrated t(11;14).
He progressed on proteasome inhibitors, immunomodulating agents, and other chemotherapy medications but later achieved very good partial response (VGPR) to venetoclax and dexamethasone.
Given the poor prognosis of pPCL, further studies using venetoclax alone or in combination with other novel agents as first-line treatment options are warranted particularly in patients with t(11;14).
American Psychological Association (APA)
Valliani, Salimah& Ali, Mir& Mahmoo, Omar& Hinduja, Sanjay& Chen, Calvin K.& Damon, Lloyd…[et al.]. 2020. Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147801
Modern Language Association (MLA)
Valliani, Salimah…[et al.]. Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review. Case Reports in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147801
American Medical Association (AMA)
Valliani, Salimah& Ali, Mir& Mahmoo, Omar& Hinduja, Sanjay& Chen, Calvin K.& Damon, Lloyd…[et al.]. Efficacy of Venetoclax and Dexamethasone in Refractory IgM Primary Plasma Cell Leukemia with t(11;14) and TP53 Mutation: A Case Report and Literature Review. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147801