A Rare CD4−CD8+ Adult T-Cell LeukemiaLymphoma with Unique Molecular Mutations: A Case Report with Literature Review
Joint Authors
Choudhuri, Jui
Geiser Roberts, Leah
Wang, Yanhua
Fang, Yanan
Zhang, Yan
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-10-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell neoplasm caused by infection of the human T-cell lymphotropic virus type 1 (HTLV-1).
Most ATLL cases are CD4-positive and CD8-negative.
Though rare, there are a few dual negative (CD4−CD8−), dual positive (CD4+CD8+), and CD4−CD8+ cases reported in literature.
ATLL is associated with HTLV-1 infection, but HTLV-1 alone cannot cause the malignant transformation of infected T cells.
Additional genetic and/or epigenetic events are required for the development of the disease.
Here, we report an unusual CD4−CD8+ATLL in a 76-year-old male with a unique molecular genetic profile.
Molecular studies revealed alterations in 10 genes.
Three of them are predicted to be pathogenic by the computational models, including the frameshift change in ZFHX4 and missense mutations in RHOA and POT1.
The specific mutations of POT1 (c.281A > G; p.Q94R), RHOA (c.47G > A; p.C16Y), and ZFHX4 (c.2871delC; p.F958Sfs∗31) have never been previously reported in ATLL to the best of our knowledge.
The clinical significance of other genetic alterations is unknown.
Further research is warranted to correlate this patient’s molecular findings with other ATLL cases.
Correlation specifically with other cases of CD8+ ATLL could prove to be useful in understanding the pathogenesis of this rare variant of an already rare form of leukemia/lymphoma.
American Psychological Association (APA)
Choudhuri, Jui& Geiser Roberts, Leah& Zhang, Yan& Wang, Yanhua& Fang, Yanan. 2020. A Rare CD4−CD8+ Adult T-Cell LeukemiaLymphoma with Unique Molecular Mutations: A Case Report with Literature Review. Case Reports in Hematology،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147878
Modern Language Association (MLA)
Choudhuri, Jui…[et al.]. A Rare CD4−CD8+ Adult T-Cell LeukemiaLymphoma with Unique Molecular Mutations: A Case Report with Literature Review. Case Reports in Hematology No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1147878
American Medical Association (AMA)
Choudhuri, Jui& Geiser Roberts, Leah& Zhang, Yan& Wang, Yanhua& Fang, Yanan. A Rare CD4−CD8+ Adult T-Cell LeukemiaLymphoma with Unique Molecular Mutations: A Case Report with Literature Review. Case Reports in Hematology. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1147878
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1147878