ANCA-Associated Intrahepatic Duct Injury Associated with Levamisole-Adulterated Cocaine

Abstract EN

Damage to the liver or kidney can occur through direct toxic effects; however, damage can also be drug-induced immune-mediated.

Levamisole-adulterated cocaine (LAC) is known to cause antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis and glomerulonephritis leading to acute kidney injury and end-stage renal disease.

It remains unclear whether LAC is associated with hepatic duct damage.

Here, we report a case with biopsy-proven evidence of intrahepatic duct damage months after being diagnosed with ANCA-associated crescentic and sclerosing glomerulonephritis caused by LAC use.

This case represents the first report of LAC-induced ANCA-associated hepatic duct cholestasis in the setting of previous LAC-induced ANCA-positive glomerulonephritis.