Brown and Red Seaweeds Serve as Potential Efflux Pump Inhibitors for Drug-Resistant Escherichia coli
Joint Authors
Lu, Wen-Jung
Lin, Hsuan-Ju
Hsu, Pang-Hung
Lai, Margaret
Chiu, Jen-Yu
Lin, Hong-Ting Victor
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Multidrug-resistant pathogens are a significant clinical problem.
Efflux pump inhibitors (EPIs) can restore the activities of existing antibiotics by interfering with drug efflux pumps located in bacterial cell membranes.
Seaweeds are important sources of biologically active metabolites of natural origin; however, their potential as EPIs remains uninvestigated.
Here, functional extracts from the brown seaweeds Laminaria japonica and Sargassum horneri and the red seaweeds Gracilaria sp.
and Porphyra dentata were evaluated as potential EPIs against drug-resistant Escherichia coli.
All these extracts were found to potentiate the activities of drugs in modulation tests, although not to the same extent.
Synergistic effects of the extracts and the drug clarithromycin were observed from the onset of Time-kill assays, with no evidence of bacterial regrowth.
Ethidium bromide accumulation studies revealed that the efflux decreased in the presence of each extract, as indicated by the presence of EPIs.
Most identified EPIs that have been discovered to date have aromatic structures, and the seaweed extracts were found to contain various terpenes, terpenoids, phenolic compounds, indoles, pyrrole derivatives, alkaloids, and halogenated aromatic compounds.
Our study highlights the potential of these compounds of the seaweeds as drug EPIs.
American Psychological Association (APA)
Lu, Wen-Jung& Lin, Hsuan-Ju& Hsu, Pang-Hung& Lai, Margaret& Chiu, Jen-Yu& Lin, Hong-Ting Victor. 2019. Brown and Red Seaweeds Serve as Potential Efflux Pump Inhibitors for Drug-Resistant Escherichia coli. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148730
Modern Language Association (MLA)
Lu, Wen-Jung…[et al.]. Brown and Red Seaweeds Serve as Potential Efflux Pump Inhibitors for Drug-Resistant Escherichia coli. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1148730
American Medical Association (AMA)
Lu, Wen-Jung& Lin, Hsuan-Ju& Hsu, Pang-Hung& Lai, Margaret& Chiu, Jen-Yu& Lin, Hong-Ting Victor. Brown and Red Seaweeds Serve as Potential Efflux Pump Inhibitors for Drug-Resistant Escherichia coli. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1148730
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1148730