A Pediatric Case of Cowden Syndrome with Graves’ Disease
Joint Authors
Patraquim, Cláudia
Fernandes, Vera
Martins, Sofia
Antunes, Ana
Marques, Olinda
Carvalho, José Luís
Correia-Pinto, Jorge
Meireles, Carla
Ferreira, Ana Margarida
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Cowden syndrome (CS) is a rare dominantly inherited multisystem disorder, characterized by an extraordinary malignant potential.
In 80% of cases, the human tumor suppressor gene phosphatase and tensin homolog (PTEN) is mutated.
We present a case of a 17-year-old boy with genetically confirmed CS and Graves’ disease (GD).
At the age of 15, he presented with intention tremor, palpitations, and marked anxiety.
On examination, he had macrocephaly, coarse facies, slight prognathism, facial trichilemmomas, abdominal keratoses, leg hemangioma, and a diffusely enlarged thyroid gland.
He started antithyroid drug (ATD) therapy with methimazole and, after a 2-year treatment period without achieving a remission status, a total thyroidectomy was performed.
Diagnosis and management of CS should be multidisciplinary.
Thyroid disease is frequent, but its management has yet to be fully defined.
The authors present a case report of a pediatric patient with CS and GD and discuss treatment options.
American Psychological Association (APA)
Patraquim, Cláudia& Fernandes, Vera& Martins, Sofia& Antunes, Ana& Marques, Olinda& Carvalho, José Luís…[et al.]. 2017. A Pediatric Case of Cowden Syndrome with Graves’ Disease. Case Reports in Pediatrics،Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1149263
Modern Language Association (MLA)
Patraquim, Cláudia…[et al.]. A Pediatric Case of Cowden Syndrome with Graves’ Disease. Case Reports in Pediatrics No. 2017 (2017), pp.1-4.
https://search.emarefa.net/detail/BIM-1149263
American Medical Association (AMA)
Patraquim, Cláudia& Fernandes, Vera& Martins, Sofia& Antunes, Ana& Marques, Olinda& Carvalho, José Luís…[et al.]. A Pediatric Case of Cowden Syndrome with Graves’ Disease. Case Reports in Pediatrics. 2017. Vol. 2017, no. 2017, pp.1-4.
https://search.emarefa.net/detail/BIM-1149263
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1149263