Glioblastoma with Both Oligodendroglioma and Primitive Neuroectodermal Tumor-Like Components in a Case with 9-Year Survival

Abstract EN

Introduction.

Glioblastoma multiforme (GBM), the most common primary malignant brain tumor in adults, is characterized by extensive heterogeneity in its clinicopathological presentation.

A primary brain tumor with both astrocytic differentiation and neuronal immunophenotype features is rare.

Here, we report a long-term survival patient who presented this rare form of GBM in the disease course.

Presentation of Case.

A 23-year-old woman, presenting with rapidly progressive headache and right-side weakness, was diagnosed with brain tumor over the left basal ganglion.

She underwent the first craniectomy for tumor removal, and histopathology revealed classic GBM.

Tumor recurrence occurred 8 years later.

Another gross total resection was performed and pathology revealed GBM with the oligodendroglioma component (GBM-O).

Due to disease progression, she received debulking surgery the following year.

The third pathology revealed glioblastoma with primitive neuroectodermal tumor-like component (GBM-PNET).

Discussion.

GBM-PNETs are collision tumors with both neuronal and glial components.

They are rare, and a few case reports have suggested that these tumors are associated with favorable outcomes but a higher risk of cerebrospinal fluid dissemination.

Conclusion.

We report a patient who developed the distinct pathologic variants of classic GBM, GBM-O, and GBM-PNET, throughout the disease course.

Young age, aggressive surgical resection, and pathologic and genetic features may have contributed to the long-term survival of the patient.