Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography
Joint Authors
Behr, Jürgen
Götschke, Jeremias
Mertsch, Pontus
Kneidinger, Nikolaus
Kauffmann-Guerrero, Diego
Huber, Rudolf Maria
Reichenberger, Frank
Milger, Katrin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Chronic hypoxia causes pulmonary vascular remodeling resulting in persistently increased pulmonary arterial pressures (PAP) even after return to normoxia.
Recently, interest in chronic intermittent hypobaric hypoxia (CIHH) was raised because it occurs in subjects working at high altitude (HA) but living in lowland.
However, effects of daily CIHH on PAP are unknown.
In this pilot study, we included 8 healthy subjects working at (2650 m) each workday for 8-9 h while living and sleeping at LA and 8 matched control subjects living and working at LA.
Cardiorespiratory measurements including echocardiography at rest and during exercise were performed at LA (Munich, 530 m) and HA (Zugspitze, 2650 m).
Hemoglobin was higher in CIHH subjects.
LA echocardiography showed normal right and left cardiac dimensions and function in all subjects.
Systolic PAP (sPAP) and tricuspid annular plane systolic excursion (TAPSE) at rest were similar in both groups.
Resting blood gas analysis (BGA) at HA revealed decreased pCO2 in CIHH compared to controls (HA: 28.4 versus 31.7 mmHg, p=0.01).
During exercise, sPAP was lower in CIHH subjects compared to controls (LA: 28.7 versus 35.3 mmHg, p=0.02; HA: 26.3 versus 33.6 mmHg, p=0.04) and peripheral oxygen saturation (SpO2) was higher.
In sum, subjects exposed to CIHH showed no signs of pulmonary vascular remodeling.
American Psychological Association (APA)
Götschke, Jeremias& Mertsch, Pontus& Kneidinger, Nikolaus& Kauffmann-Guerrero, Diego& Behr, Jürgen& Huber, Rudolf Maria…[et al.]. 2018. Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography. Canadian Respiratory Journal،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1151936
Modern Language Association (MLA)
Götschke, Jeremias…[et al.]. Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography. Canadian Respiratory Journal No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1151936
American Medical Association (AMA)
Götschke, Jeremias& Mertsch, Pontus& Kneidinger, Nikolaus& Kauffmann-Guerrero, Diego& Behr, Jürgen& Huber, Rudolf Maria…[et al.]. Daily Chronic Intermittent Hypobaric Hypoxia Does Not Induce Chronic Increase in Pulmonary Arterial Pressure Assessed by Echocardiography. Canadian Respiratory Journal. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1151936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1151936