Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr

Joint Authors

Wei, Fenfen
He, Qinghua
Wang, Wenjuan
Pei, Dong
Zhang, Bo

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-03-04

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Cynomorium songaricum Rupr, known as Suo Yang, is most commonly used to treat fatigue, protect the liver, and invigorate kidneys in Northwest China.

Given the wide medicinal utilisation and lack of safety evaluation, this work evaluated the acute toxicity, genetic toxicity, and 90-day repeated oral toxicity of Suo Yang.

Twenty Kunming mice were orally given Suo Yang once and observed for 14 days in the acute toxicity test.

The genetic toxicity of Suo Yang was tested using in vivo and vitro assays (bacterial reverse mutation test, mouse bone marrow micronucleus assay, and spermatocyte chromosomal aberration assay).

In the 90-day repeated oral toxicity study, 80 SD rats were randomly divided into 4 groups and then orally given Suo Yang at different concentrations (1.04, 2.08 or 4.16 g/kg), while the control group was given sterile water.

In the acute toxicity test, no abnormal behaviour or mortality was found in mice.

The results suggest that the maximum tolerable dose of Suo Yang is greater than 15 g/kg.

In the genotoxicity studies, no revertant colonies were produced in vitro.

In the in vivo assays, no increased frequencies of micronuclei or structural abnormalities of spermatocyte chromosomes were found.

In the 90-day repeated oral toxicity study, no significant toxicological manifestations were observed in haematological parameters or clinical and pathological examinations.

In summary, these results suggest that Suo Yang at the given doses does not cause adverse effects in animals.

Thus, Suo Yang can reasonably be considered a safe herbal medicine.

American Psychological Association (APA)

Wei, Fenfen& He, Qinghua& Wang, Wenjuan& Pei, Dong& Zhang, Bo. 2019. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr. Evidence-Based Complementary and Alternative Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151952

Modern Language Association (MLA)

Wei, Fenfen…[et al.]. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr. Evidence-Based Complementary and Alternative Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1151952

American Medical Association (AMA)

Wei, Fenfen& He, Qinghua& Wang, Wenjuan& Pei, Dong& Zhang, Bo. Toxicity Assessment of Chinese Herbal Medicine Cynomorium songaricum Rupr. Evidence-Based Complementary and Alternative Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1151952

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1151952