Detection of Viruses by Multiplex Real-Time Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of Patients with Nonresponding Community-Acquired Pneumonia
Joint Authors
Zhang, Rong
Huang, Huaqiong
Wang, Shaobin
Zhou, Hongwei
Han, Yinling
Jin, Zhangchu
Ying, Yinghua
Lan, Fen
Hua, Wen
Shen, Huahao
Li, Wen
Yan, Fugui
Zhang, Hao
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-11-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Nonresponding pneumonia is responsible for the most mortality of community-acquired pneumonia (CAP).
However, thus far, it is not clear whether viral infection plays an important role in the etiology of nonresponding CAP and whether there is a significant difference in the clinical characteristics between viral and nonviral nonresponding CAP.
Methods.
From 2016 to 2019, nonresponding CAP patients were retrospectively enrolled in our study.
All patients received bronchoalveolar lavage (BAL) and virus detection in BAL fluid by multiplex real-time polymerase chain reaction (PCR), and clinical, laboratory, and radiographic data were collected.
Results.
A total of 43 patients were included.
The median age was 62 years, and 65.1% of patients were male.
Overall, 20 patients (46.5%) were identified with viral infection.
Of these viruses, influenza virus (n = 8) and adenovirus (n = 7) were more frequently detected, and others included herpes simplex virus, human enterovirus, cytomegalovirus, human coronavirus 229E, rhinovirus, and parainfluenza virus.
Compared with nonviral nonresponding CAP, only ground-glass opacity combined with consolidation was a more common imaging manifestation in viral nonresponding CAP.
However, no obvious differences were found in clinical and laboratory findings between the presence and the absence of viral infections.
Conclusions.
Viral infections were particularly frequent in adults with nonresponding CAP.
The ground-glass opacity combined with consolidation was a specific imaging manifestation for viral nonresponding CAP, while the clinical and laboratory data showed no obvious differences between viral and nonviral nonresponding CAP.
American Psychological Association (APA)
Zhang, Hao& Han, Yinling& Jin, Zhangchu& Ying, Yinghua& Lan, Fen& Huang, Huaqiong…[et al.]. 2020. Detection of Viruses by Multiplex Real-Time Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of Patients with Nonresponding Community-Acquired Pneumonia. Canadian Respiratory Journal،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152228
Modern Language Association (MLA)
Zhang, Hao…[et al.]. Detection of Viruses by Multiplex Real-Time Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of Patients with Nonresponding Community-Acquired Pneumonia. Canadian Respiratory Journal No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1152228
American Medical Association (AMA)
Zhang, Hao& Han, Yinling& Jin, Zhangchu& Ying, Yinghua& Lan, Fen& Huang, Huaqiong…[et al.]. Detection of Viruses by Multiplex Real-Time Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of Patients with Nonresponding Community-Acquired Pneumonia. Canadian Respiratory Journal. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1152228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152228