Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Joint Authors

Li, Ben
Hou, Jiaqi
Yang, Yue
Piao, Xuemei
Chen, Yueying
Wang, Dan
Hu, Jiandong
Li, Guoling
Wu, Xiangxiang
Sun, Yu
Jin, Runa
Xue, Luan

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-07-10

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Medicine

Abstract EN

Objective.

To evaluate the clinical therapeutic efficacy and safety of JieDuTongLuoShengJin granules + HCQ in patients with pSS.

Methods.

40 patients with low-activity-level pSS and without visceral involvement participated in this study and were randomized to receive either JieDuTongLuoShengJin granules with HCQ or placebo with HCQ.

Patients and investigators were blinded to treatment allocation.

The primary endpoint was week 12 ESSPRI score, while secondary endpoints included ESSDAI, salivary and lacrimal gland function, and some laboratory variables.

Safety-related data were also assessed.

Results.

Comparing with the placebo group, the treatment group experienced statistically significant improvement in the mean change from baseline for the primary endpoint of ESSPRI score and also in PGA.

Moreover, in comparison with baseline values, the treatment group had significantly improved ESSDAI score, unstimulated saliva flow rate, and several laboratory variables.

However, upon comparison of the two groups, there were no significant differences for them.

The incidence of AEs was 10.0%, one in treatment group and three in placebo group.

Conclusion.

Treatment with a combination of JieDuTongLuoShengJin granules with HCQ is effective in improving patients’ subjective symptoms and some objective indicators of pSS.

These results indicate that JieDuTongLuoShengJin is promising as a safe and effective treatment of pSS.

American Psychological Association (APA)

Li, Ben& Hou, Jiaqi& Yang, Yue& Piao, Xuemei& Chen, Yueying& Xue, Luan…[et al.]. 2017. Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152975

Modern Language Association (MLA)

Li, Ben…[et al.]. Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1152975

American Medical Association (AMA)

Li, Ben& Hou, Jiaqi& Yang, Yue& Piao, Xuemei& Chen, Yueying& Xue, Luan…[et al.]. Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1152975

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1152975