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Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo
Joint Authors
Oh, Won Keun
Tabassum, Nadia
Jung, Da-Woon
Williams, Darren R.
Lee, Ji-Hyung
Yim, Soon-Ho
Kim, Hyun-Jung
Kim, Woong-Hee
Cho, Haaglim
Batkhuu, Galzad J.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Abnormalities in skin pigmentation can produce disorders such as albinism or melasma.
There is a research need to discover novel compounds that safely and effectively regulate pigmentation.
To identify novel modulators of pigmentation, we attempted to purify compounds from a bioactive fraction of the Korean medicinal plant Artemisia capillaris Thunberg.
The novel compound isofraxidin 7-O-(6′-O-p-coumaroyl)-β-glucopyranoside (compound 1) was isolated and its pigmentation activity was characterized in mammalian melanocytes.
Compound 1 stimulated melanin accumulation and increased tyrosinase activity, which regulates melanin synthesis.
Moreover, compound 1 increased the expression of tyrosinase and the key melanogenesis regulator microphthalmia-associated transcription factor (MITF) in melanocytes.
Compared to the parent compound, isofraxidin, compound 1 produced greater effects on these pigmentation parameters.
To validate compound 1 as a novel hyperpigmentation agent in vivo, we utilized the zebrafish vertebrate model.
Zebrafish treated with compound 1 showed higher melanogenesis and increased tyrosinase activity.
Compound 1 treated embryos had no developmental defects and displayed normal cardiac function, indicating that this compound enhanced pigmentation without producing toxicity.
In summary, our results describe the characterization of novel natural product compound 1 and its bioactivity as a pigmentation enhancer, demonstrating its potential as a therapeutic to treat hypopigmentation disorders.
American Psychological Association (APA)
Yim, Soon-Ho& Tabassum, Nadia& Kim, Woong-Hee& Cho, Haaglim& Lee, Ji-Hyung& Batkhuu, Galzad J.…[et al.]. 2017. Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1152990
Modern Language Association (MLA)
Yim, Soon-Ho…[et al.]. Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1152990
American Medical Association (AMA)
Yim, Soon-Ho& Tabassum, Nadia& Kim, Woong-Hee& Cho, Haaglim& Lee, Ji-Hyung& Batkhuu, Galzad J.…[et al.]. Isolation and Characterization of Isofraxidin 7-O-(6′-O-p-Coumaroyl)-β-glucopyranoside from Artemisia capillaris Thunberg: A Novel, Nontoxic Hyperpigmentation Agent That Is Effective In Vivo. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1152990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1152990