Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease
Joint Authors
de Morais, Selene Maia
Penido, Alexandre Batista
Ribeiro, Alan Bezerra
Alves, Daniela Ribeiro
Rodrigues, Ana Livya Moreira
dos Santos, Leonardo Hunaldo
de Menezes, Jane Eire Silva Alencar
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Alzheimer’s disease (AD) has been linked with oxidative stress, acetylcholine deficiency in the brain, and inflammatory processes.
In the northeast region of Brazil, various plants are used to treat several diseases associated with these processes; then an antioxidant test was performed with those plants in a previous work and twelve species with higher antioxidant activity were selected for AChE inhibition evaluation.
The phenolic compounds content was determined by Folin–Ciocalteu test and flavonoid content with AlCl3 reagent using UV-visible spectrophotometry.
The antioxidant activity was assessed analyzing the inhibitory activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2-azinobis-3-ethylbenzothiazoline-6-sulfonate (ABTS) and by the β-carotene/linoleic acid system and acetylcholinesterase inhibition using qualitative and quantitative tests.
The combination of better acetylcholinesterase inhibitory and antioxidant activities pointed out six species, in descending order, as the best potential sources of therapeutic agents against AD: Hancornia speciosa > Myracrodruon urundeuva > Copaifera langsdorffii > Stryphnodendron coriaceum > Psidium guajava > Mangifera indica.
Besides, the phenolic compounds in the species probably contribute to these activities.
However, further pharmacological studies to assess the specific applications of these plants against AD are required to confirm these results.
American Psychological Association (APA)
Penido, Alexandre Batista& de Morais, Selene Maia& Ribeiro, Alan Bezerra& Alves, Daniela Ribeiro& Rodrigues, Ana Livya Moreira& dos Santos, Leonardo Hunaldo…[et al.]. 2017. Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153081
Modern Language Association (MLA)
Penido, Alexandre Batista…[et al.]. Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1153081
American Medical Association (AMA)
Penido, Alexandre Batista& de Morais, Selene Maia& Ribeiro, Alan Bezerra& Alves, Daniela Ribeiro& Rodrigues, Ana Livya Moreira& dos Santos, Leonardo Hunaldo…[et al.]. Medicinal Plants from Northeastern Brazil against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1153081
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153081