Interleukin-34 Synovial Fluid Was Associated with Knee Osteoarthritis Severity: A Cross-Sectional Study in Knee Osteoarthritis Patients in Different Radiographic Stages
Joint Authors
Wang, Shuang-Lei
Zhang, Rui
Hu, Kong-Zu
Li, Mao-Qiang
Li, Zhan-Chun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Inflammation might play a crucial role in the pathogenesis of osteoarthritis (OA).
Interleukin-34 (IL-34) is a well-known proinflammatory cytokine.
Objective.
The objective of this study was to detect IL-34 levels in serum and synovial fluid (SF) of patients with OA and to investigate their correlation with radiographic and symptomatic severity.
Methods.
One hundred and eighty-two OA patients and 69 controls were recruited.
IL-34 levels were measured by enzyme-linked immunosorbent assay (ELISA).
Radiographic and symptomatic severity of OA was reflected by Kellgren-Lawrence (KL) grades and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores, respectively.
Results.
SF IL-34 levels were independently associated with the KL grade (B=0.273, 95% CI: 0.150–0.395; P<0.001).
SF IL-34 levels were significantly correlated with WOMAC scores (r=0.265, 95% CI: 0.123–0.399; P<0.001).
The correlation between SF IL-34 levels and WOMAC scores was still significant after adjusting for confounding factors (B=0.020, 95% CI: 0.001–0.038; P=0.035) in OA patients.
Conclusions.
We found that IL-34 levels in SF were significantly associated with the radiographic and symptomatic severity of knee OA.
American Psychological Association (APA)
Wang, Shuang-Lei& Zhang, Rui& Hu, Kong-Zu& Li, Mao-Qiang& Li, Zhan-Chun. 2018. Interleukin-34 Synovial Fluid Was Associated with Knee Osteoarthritis Severity: A Cross-Sectional Study in Knee Osteoarthritis Patients in Different Radiographic Stages. Disease Markers،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153147
Modern Language Association (MLA)
Wang, Shuang-Lei…[et al.]. Interleukin-34 Synovial Fluid Was Associated with Knee Osteoarthritis Severity: A Cross-Sectional Study in Knee Osteoarthritis Patients in Different Radiographic Stages. Disease Markers No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1153147
American Medical Association (AMA)
Wang, Shuang-Lei& Zhang, Rui& Hu, Kong-Zu& Li, Mao-Qiang& Li, Zhan-Chun. Interleukin-34 Synovial Fluid Was Associated with Knee Osteoarthritis Severity: A Cross-Sectional Study in Knee Osteoarthritis Patients in Different Radiographic Stages. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1153147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153147