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TGF-β Polymorphisms Are a Risk Factor for Chagas Disease
Joint Authors
Cabello, Pedro Hernan
Ferreira, Roberto Rodrigues
Madeira, Fabiana da Silva
Alves, Gabriel Farias
Chambela, Mayara da Costa
Curvo, Eduardo de Oliveira Vaz
Moreira, Aline dos Santos
Almeida de Sá, Renata
Mendonça-Lima, Leila
Bailly, Sabine
Feige, Jean-Jacques
Araujo-Jorge, Tania Cremonini
Saraiva, Roberto Magalhães
Waghabi, Mariana Caldas
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Transforming growth factor β1 (TGF-β1) is an important mediator in Chagas disease.
Furthermore, patients with higher TGF-β1 serum levels show a worse clinical outcome.
Gene polymorphism may account for differences in cytokine production during infectious diseases.
We tested whether TGFB1 polymorphisms could be associated with Chagas disease susceptibility and severity in a Brazilian population.
We investigated five single-nucleotide polymorphisms (−800 G>A, −509 C>T, +10 T>C, +25 G>C, and +263 C>T).
152 patients with Chagas disease (53 with the indeterminate form and 99 with the cardiac form) and 48 noninfected subjects were included.
Genotypes CT and TT at position −509 of the TGFB1 gene were more frequent in Chagas disease patients than in noninfected subjects.
Genotypes TC and CC at codon +10 of the TGFB1 gene were also more frequent in Chagas disease patients than in noninfected subjects.
We found no significant differences in the distribution of the studied TGFB1 polymorphisms between patients with the indeterminate or cardiac form of Chagas disease.
Therefore, −509 C>T and +10 T>C TGFB1 polymorphisms are associated with Chagas disease susceptibility in a Brazilian population.
American Psychological Association (APA)
Ferreira, Roberto Rodrigues& Madeira, Fabiana da Silva& Alves, Gabriel Farias& Chambela, Mayara da Costa& Curvo, Eduardo de Oliveira Vaz& Moreira, Aline dos Santos…[et al.]. 2018. TGF-β Polymorphisms Are a Risk Factor for Chagas Disease. Disease Markers،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153347
Modern Language Association (MLA)
Ferreira, Roberto Rodrigues…[et al.]. TGF-β Polymorphisms Are a Risk Factor for Chagas Disease. Disease Markers No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1153347
American Medical Association (AMA)
Ferreira, Roberto Rodrigues& Madeira, Fabiana da Silva& Alves, Gabriel Farias& Chambela, Mayara da Costa& Curvo, Eduardo de Oliveira Vaz& Moreira, Aline dos Santos…[et al.]. TGF-β Polymorphisms Are a Risk Factor for Chagas Disease. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1153347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153347