Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer’s Disease
Joint Authors
Zhou, Xin-Fu
Liang, Chen
Yuan, Jian-Ping
Ding, Tao
Yan, Lv
Ling, Lu
Zeng, Yue-Qin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Accumulated evidence suggests that polyphenolic antioxidants present in herbs play important roles in prevention of AD; the molecular mechanisms behind neuroprotective actions rely on the phenols through different effects on the amyloid-aggregation pathway.
Fagopyrum dibotrys is a traditional herbal medicine which contains high quantity phenols.
In present study, we investigate the beneficial pharmacological actions of Fagopyrum dibotrys extract in the APP/PS1 transgenic mouse mode; meanwhile, effects of the FDE on the fibrillation and cytotoxicity of Aβ peptide were evaluated in vitro.
After 9-month treatment, FDE exhibited multifunctional properties on Aβ-related pathologies, which cleaned Aβ deposits in the brain and decreased Aβ burden in the plasma, inhibited microhaemorrhage, and reduced reactive microglia in APP/PS1 transgenic mice and also promoted Aβ fibrils disaggregation and inhibited neurotoxicity induced by Aβ in SH-SY5Y cells.
These results highlighted that FDE is an AD type pathology modulator with therapeutic potential against AD.
American Psychological Association (APA)
Liang, Chen& Yuan, Jian-Ping& Ding, Tao& Yan, Lv& Ling, Lu& Zhou, Xin-Fu…[et al.]. 2017. Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153488
Modern Language Association (MLA)
Liang, Chen…[et al.]. Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1153488
American Medical Association (AMA)
Liang, Chen& Yuan, Jian-Ping& Ding, Tao& Yan, Lv& Ling, Lu& Zhou, Xin-Fu…[et al.]. Neuroprotective Effect of Fagopyrum dibotrys Extract against Alzheimer’s Disease. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1153488
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153488