Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
Joint Authors
Yan, Pijun
Wan, Qin
Feng, Jian
Li, Hua
Yang, Jun
Zhong, Haihua
Xu, Yong
Zhang, Zhihong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Neuregulin 4 (Nrg4) has been proposed to play a role in the pathogeneses of obesity, insulin resistance, and dyslipidemia.
However, information about the link between Nrg4 and metabolic syndrome (MetS) is scarce, especially in patients with newly diagnosed type 2 diabetes mellitus (nT2DM).
This study aimed at investigating whether Nrg4 is associated with MetS in nT2DM patients.
A total of 311 patients with nT2DM were recruited.
Plasma Nrg4 concentration was determined by ELISA.
Plasma Nrg4 concentration was lower in nT2DM patients with MetS than in nT2DM patients without MetS (P=0.001).
Nrg4 concentration showed negative correlations with most of the analyzed indicators of MetS.
MetS was less prevalent among subjects in the highest quartile of plasma Nrg4 concentration than among those in the lowest quartile (P<0.01).
Age- and sex-adjusted plasma Nrg4 concentrations were positively correlated with concentrations of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (both P<0.05) and negatively correlated with triglyceride, high-sensitivity C-reactive protein (hs-CRP), and gamma-glutamyltransferase concentrations, neutrophil count, and white blood cell (WBC) count (all P<0.05).
In multivariate analysis, Nrg4 was independently associated with hs-CRP level, WBC count, and HDL-C level (P=0.001 or P<0.05).
Multiple logistic regression analysis of MetS prediction by Nrg4 revealed an odds ratio of 0.560 (95% CI: 0.374–0.837; P<0.01).
Decreased plasma Nrg4 levels, which may be associated with augmented oxidative stress, inflammation, and dyslipidemia, might be involved in the development of MetS in nT2DM patients.
American Psychological Association (APA)
Yan, Pijun& Xu, Yong& Wan, Qin& Feng, Jian& Li, Hua& Yang, Jun…[et al.]. 2018. Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus. Disease Markers،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153568
Modern Language Association (MLA)
Yan, Pijun…[et al.]. Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus. Disease Markers No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1153568
American Medical Association (AMA)
Yan, Pijun& Xu, Yong& Wan, Qin& Feng, Jian& Li, Hua& Yang, Jun…[et al.]. Plasma Neuregulin 4 Levels Are Associated with Metabolic Syndrome in Patients Newly Diagnosed with Type 2 Diabetes Mellitus. Disease Markers. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1153568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153568