Effect of Shin’iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation
Joint Authors
Minami, Masaaki
Makino, Toshiaki
Takase, Hiroshi
Konishi, Toru
Jiang, Zhixia
Arai, Tetsuya
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Streptococcus pneumoniae (S.
pneumoniae) causes sinusitis.
The general treatment of S.
pneumonia sinusitis is by using antibiotics; however, one of their serious problems is the attenuation of their effect.
Shin’iseihaito (Xinyiqingfeitang), a formula of Japanese traditional Kampo medicine, has been used for the treatment of sinusitis in Japan.
In this study, we investigated the efficacy of Shin’iseihaito against S.
pneumoniae-caused sinusitis in mice.
Oral administration of Shin’iseihaito extract (SSHT) decreased the nasal colonization of S.
pneumoniae in both prophylactic and therapeutic treatments, respectively, and the former was more effective than the latter.
Histopathological analysis revealed that the epithelial tissue from S.
pneumoniae-infected nose under SSHT treatment recovered the tissue destruction in comparison to infected nose.
We also confirmed this result by scanning electron microscopic analysis.
Murine peritoneal macrophages from SSHT-treated mice had significant phagocytic activity in comparison to those from untreated group.
We also found that tumor necrosis factor-α, interleukin-1β, interleukin-6, and monocyte chemotactic protein-1 levels and the migration of macrophages from S.
pneumoniae-infected mice with the treatment with SSHT were increased compared to those from untreated group.
Our data suggest that Shin’iseihaito may be useful for the treatment of S.
pneumoniae-induced sinusitis.
American Psychological Association (APA)
Minami, Masaaki& Konishi, Toru& Takase, Hiroshi& Jiang, Zhixia& Arai, Tetsuya& Makino, Toshiaki. 2017. Effect of Shin’iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153711
Modern Language Association (MLA)
Minami, Masaaki…[et al.]. Effect of Shin’iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1153711
American Medical Association (AMA)
Minami, Masaaki& Konishi, Toru& Takase, Hiroshi& Jiang, Zhixia& Arai, Tetsuya& Makino, Toshiaki. Effect of Shin’iseihaito (Xinyiqingfeitang) on Acute Streptococcus pneumoniae Murine Sinusitis via Macrophage Activation. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1153711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1153711