Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women

Joint Authors

Mohammed, Abdul Khader
Bukhari, Ihtisham
Hussain, Syed Danish
Abdi, Saba
Ansari, Mohammed G. A.
BinBaz, Rawan A.
Aljohani, Naji
Al-Daghri, Nasser M.

Source

Disease Markers

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-10

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Diseases

Abstract EN

The RANKL/RANK/OPG pathway regulates bone remodelling and turnover.

However, the genetic background of bone mineral density (BMD) and osteopenia in Saudi postmenopausal women is yet to be studied.

We studied the genetic polymorphism of RANKL/RANK/OPG with BMD and other associated factors in Saudi postmenopausal osteopenic women.

A total of 439 (223 osteopenia and 216 control) postmenopausal women were recruited from the orthopaedic department of the King Khalid University Hospital, Riyadh, KSA.

Genetic variants of RANK (rs1805034 and rs35211496), RANKL (rs2277438 and rs9533156), and OPG (rs2073618 and rs3102735) were genotyped using RT-PCR.

Anthropometrics, bone mineral density, and other bone markers were measured.

The levels of bone turnover markers, PTH, and RANKL were found to be significantly different between control and the osteopenia group.

The odds ratio of 2.37 (1.00–5.69) for RANK SNP (rs1805034) indicates that subjects with CC genotype are more vulnerable to developing osteopenia as compared to subjects with TT genotype.

Similarly, for RANKL SNP (rs2277438), the significant odds ratio of 20.56 (9.82–43.06) indicates that the subjects with GG genotype are at significantly higher risk of having osteopenia compared with the AA genotype subjects.

In addition, G allele in rs2277438 also found to be a risk factor for osteopenia 4.54 (3.18–6.49) compared with A allele.

However, none of the OPG genotypes shows association with osteopenia.

The association of RANK polymorphisms with osteopenia shows its clinical importance in the diagnosis and prognosis of the bone diseases; here, we suggest that the subjects with RANK and RANKL polymorphisms may develop osteoporosis.

American Psychological Association (APA)

Abdi, Saba& Bukhari, Ihtisham& Ansari, Mohammed G. A.& BinBaz, Rawan A.& Mohammed, Abdul Khader& Hussain, Syed Danish…[et al.]. 2020. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153751

Modern Language Association (MLA)

Abdi, Saba…[et al.]. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1153751

American Medical Association (AMA)

Abdi, Saba& Bukhari, Ihtisham& Ansari, Mohammed G. A.& BinBaz, Rawan A.& Mohammed, Abdul Khader& Hussain, Syed Danish…[et al.]. Association of Polymorphisms in RANK and RANKL Genes with Osteopenia in Arab Postmenopausal Women. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1153751

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1153751