The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis

Joint Authors

Shao, Yi
Liu, Rongqiang
Zheng, Shiyang
Yuan, Qing
Zhu, Peiwen
Li, Biao
Lin, Qi
Shi, Wenqing
Min, Youlan
Ge, Qianmin

Source

Disease Markers

Issue

Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2020-12-10

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Purpose.

The prognostic value of a new scoring system, termed F-NLR, that combines pretreatment fibrinogen level with neutrophil-lymphocyte ratio has been evaluated in various cancers.

However, the results are controversial.

The purpose of this study was to comprehensively analyze the prognostic value of F-NLR score in patients with cancers.

Methods.

An integrated search of relevant studies was conducted by screening the PubMed and Embase databases.

Pooled hazard ratios, with 95% confidence intervals (CIs), for overall survival (OS) and disease-free survival (DFS)/progression-free survival (PFS) were calculated to estimate the prognostic significance of F-NLR score in patients with various tumors.

A random effects model was used for comprehensive analysis, and subgroup and meta-regression analyses were used to explore sources of heterogeneity.

Results.

Thirteen articles reporting data from of 4747 patients were included in the study.

Pooled analysis revealed that high F-NLR score was significantly associated with poor OS (HR=1.77; 95% CI, 1.51–2.08) and poor DFS/PFS (HR=1.63; 95% CI, 1.30–2.05).

Subgroup and meta-regression analyses did not alter the prognostic role of F-NLR score in OS and DFS/PFS.

Conclusions.

Increased F-NLR score is significantly associated with poor prognosis in patients with cancers and can serve as an effective prognostic indicator.

American Psychological Association (APA)

Liu, Rongqiang& Zheng, Shiyang& Yuan, Qing& Zhu, Peiwen& Li, Biao& Lin, Qi…[et al.]. 2020. The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis. Disease Markers،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153849

Modern Language Association (MLA)

Liu, Rongqiang…[et al.]. The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis. Disease Markers No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1153849

American Medical Association (AMA)

Liu, Rongqiang& Zheng, Shiyang& Yuan, Qing& Zhu, Peiwen& Li, Biao& Lin, Qi…[et al.]. The Prognostic Significance of Combined Pretreatment Fibrinogen and Neutrophil-Lymphocyte Ratio in Various Cancers: A Systematic Review and Meta-Analysis. Disease Markers. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1153849

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1153849