Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-κB and STAT3 Signaling
Joint Authors
Su, Dan
Gao, Yu-Qiao
Hu, Ying
Mei, Quan-Xi
Dai, Wei-bo
Wu, Yan-fen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Colorectal cancer (CRC) is one of the most common malignancies and most frequent cause of cancer death worldwide.
The activation of both NF-κB and STAT3 signaling and the crosstalk between them play an important role in colorectal tumor.
Helicteres angustifolia L.
is a type of commonly used Chinese medicinal herb and possesses a wide variety of biological activities.
In the present study, we investigate the effects of three triterpenes from H.
angustifolia (HT) such as helicteric acid (HA), oleanic acid (OA), and betulinic acid (BA), on inhibiting CRC progression.
Our results showed that HT extracts could decrease proliferation and induce apoptosis in HT-29 colorectal cancer cells.
Moreover, HT extracts could suppress LPS-triggered phosphorylation of IKK, IκB, and NF-κB, attenuate IL-6-induced phosphorylation of JAK2 and STAT3, and suppress the expression of c-Myc, cyclin-D1, and BCL-xL, the downstream gene targets of NF-κB and STAT3.
Therefore, HT extracts showed potent therapeutic and antitumor effects on CRC via inhibiting NF-κB and STAT3 signaling.
American Psychological Association (APA)
Su, Dan& Gao, Yu-Qiao& Dai, Wei-bo& Hu, Ying& Wu, Yan-fen& Mei, Quan-Xi. 2017. Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-κB and STAT3 Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154006
Modern Language Association (MLA)
Su, Dan…[et al.]. Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-κB and STAT3 Signaling. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1154006
American Medical Association (AMA)
Su, Dan& Gao, Yu-Qiao& Dai, Wei-bo& Hu, Ying& Wu, Yan-fen& Mei, Quan-Xi. Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-κB and STAT3 Signaling. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1154006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154006