Erzhi Pill® Repairs Experimental Liver Injury via TSCmTOR Signaling Pathway Inhibiting Excessive Apoptosis
Joint Authors
Xu, Rong
Wang, Xin
Zou, Yong
Yue, Hai-yang
Zhou, Bu-gao
Lu, Xiu-yun
Liu, Yi
Zuo, Zheng-yun
Liu, Duan-Yong
Zhao, Hai-Mei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-30
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The present study aimed to investigate the mechanism of hepatoprotective effect of Erzhi Pill (EZP) on the liver injury via observing TSC/mTOR signaling pathway activation.
The experimental liver injury was induced by 2-acetylaminofluorene (2-AAF) treatment combined with partial hepatectomy (PH).
EZP treated 2-AAF/PH-induced liver injury by the therapeutic and prophylactic administration.
After the administration of EZP, the activities of aspartic transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AKP), and gamma-glutamyl transpeptidase (γ-GT) were decreased, followed by the decreased levels of hepatocyte apoptosis and caspase-3 expression.
However, the secretion of albumin, liver weight, and index of liver weight were elevated.
Microscopic examination showed that EZP restored pathological liver injury.
Meanwhile, Rheb and mammalian target of rapamycin (mTOR) activation were suppressed, and tuberous sclerosis complex (TSC) expression was elevated in liver tissues induced by 2-AAF/PHx and accompanied with lower-expression of Bax, Notch1, p70S6K, and 4E-EIF and upregulated levels of Bcl-2 and Cyclin D.
Hepatoprotective effect of EZP was possibly realized via inhibiting TSC/mTOR signaling pathway to suppress excessive apoptosis of hepatocyte.
American Psychological Association (APA)
Zhou, Bu-gao& Zhao, Hai-Mei& Lu, Xiu-yun& Wang, Xin& Zou, Yong& Xu, Rong…[et al.]. 2017. Erzhi Pill® Repairs Experimental Liver Injury via TSCmTOR Signaling Pathway Inhibiting Excessive Apoptosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154091
Modern Language Association (MLA)
Zhou, Bu-gao…[et al.]. Erzhi Pill® Repairs Experimental Liver Injury via TSCmTOR Signaling Pathway Inhibiting Excessive Apoptosis. Evidence-Based Complementary and Alternative Medicine No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1154091
American Medical Association (AMA)
Zhou, Bu-gao& Zhao, Hai-Mei& Lu, Xiu-yun& Wang, Xin& Zou, Yong& Xu, Rong…[et al.]. Erzhi Pill® Repairs Experimental Liver Injury via TSCmTOR Signaling Pathway Inhibiting Excessive Apoptosis. Evidence-Based Complementary and Alternative Medicine. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1154091
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1154091